Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood

Abstract How does the neural control of fine movements develop from childhood to adulthood? Here, we investigated developmental differences in functional corticomuscular connectivity using coherence analyses in 111 individuals from four different age groups covering the age range 8–30 y. EEG and EMG...

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Autores principales:	Mikkel Malling Beck, Meaghan Elizabeth Spedden, Jesper Lundbye-Jensen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b83459e53b14ff3b7145d64c67f62a6
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spelling	oai:doaj.org-article:2b83459e53b14ff3b7145d64c67f62a62021-11-28T12:18:50ZReorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood10.1038/s41598-021-01903-12045-2322https://doaj.org/article/2b83459e53b14ff3b7145d64c67f62a62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01903-1https://doaj.org/toc/2045-2322Abstract How does the neural control of fine movements develop from childhood to adulthood? Here, we investigated developmental differences in functional corticomuscular connectivity using coherence analyses in 111 individuals from four different age groups covering the age range 8–30 y. EEG and EMG were recorded while participants performed a uni-manual force-tracing task requiring fine control of force in a precision grip with both the dominant and non-dominant hand. Using beamforming methods, we located and reconstructed source activity from EEG data displaying peak coherence with the EMG activity of an intrinsic hand muscle during the task. Coherent cortical sources were found anterior and posterior to the central sulcus in the contralateral hemisphere. Undirected and directed corticomuscular coherence was quantified and compared between age groups. Our results revealed that coherence was greater in adults (20–30 yo) than in children (8–10 yo) and that this difference was driven by greater magnitudes of descending (cortex-to-muscle), rather than ascending (muscle-to-cortex), coherence. We speculate that the age-related differences reflect maturation of corticomuscular networks leading to increased functional connectivity with age. We interpret the greater magnitude of descending oscillatory coupling as reflecting a greater degree of feedforward control in adults compared to children. The findings provide a detailed characterization of differences in functional sensorimotor connectivity for individuals at different stages of typical ontogenetic development that may be related to the maturational refinement of dexterous motor control.Mikkel Malling BeckMeaghan Elizabeth SpeddenJesper Lundbye-JensenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mikkel Malling Beck Meaghan Elizabeth Spedden Jesper Lundbye-Jensen Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
description	Abstract How does the neural control of fine movements develop from childhood to adulthood? Here, we investigated developmental differences in functional corticomuscular connectivity using coherence analyses in 111 individuals from four different age groups covering the age range 8–30 y. EEG and EMG were recorded while participants performed a uni-manual force-tracing task requiring fine control of force in a precision grip with both the dominant and non-dominant hand. Using beamforming methods, we located and reconstructed source activity from EEG data displaying peak coherence with the EMG activity of an intrinsic hand muscle during the task. Coherent cortical sources were found anterior and posterior to the central sulcus in the contralateral hemisphere. Undirected and directed corticomuscular coherence was quantified and compared between age groups. Our results revealed that coherence was greater in adults (20–30 yo) than in children (8–10 yo) and that this difference was driven by greater magnitudes of descending (cortex-to-muscle), rather than ascending (muscle-to-cortex), coherence. We speculate that the age-related differences reflect maturation of corticomuscular networks leading to increased functional connectivity with age. We interpret the greater magnitude of descending oscillatory coupling as reflecting a greater degree of feedforward control in adults compared to children. The findings provide a detailed characterization of differences in functional sensorimotor connectivity for individuals at different stages of typical ontogenetic development that may be related to the maturational refinement of dexterous motor control.
format	article
author	Mikkel Malling Beck Meaghan Elizabeth Spedden Jesper Lundbye-Jensen
author_facet	Mikkel Malling Beck Meaghan Elizabeth Spedden Jesper Lundbye-Jensen
author_sort	Mikkel Malling Beck
title	Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
title_short	Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
title_full	Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
title_fullStr	Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
title_full_unstemmed	Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
title_sort	reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2b83459e53b14ff3b7145d64c67f62a6
work_keys_str_mv	AT mikkelmallingbeck reorganizationoffunctionalanddirectedcorticomuscularconnectivityduringprecisiongripfromchildhoodtoadulthood AT meaghanelizabethspedden reorganizationoffunctionalanddirectedcorticomuscularconnectivityduringprecisiongripfromchildhoodtoadulthood AT jesperlundbyejensen reorganizationoffunctionalanddirectedcorticomuscularconnectivityduringprecisiongripfromchildhoodtoadulthood
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Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood

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