LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES

Abstract. We investigated effects of combined oral contraceptives (COC) containing low- and microdoses of estrogenic components upon serum levels of macroglobulin family proteins (alpha-2-macroglobulin, α2-MG, and pregnancy-associated alpha-2-glycoprotein, α2-PAG), their immune complexes with IgG, a...

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Autores principales:	V. N. Zorina, E. V. Keremetskaya, L. G. Bagenova, R. M. Zorina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	combined oral contraceptives malignant proliferation risk alpha-2-macroglobulin pregnancy-associated alpha-2-glycoprotein cytokines immune complexes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2b897c3552bb49b5b21092d9de246afe
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spelling	oai:doaj.org-article:2b897c3552bb49b5b21092d9de246afe2021-11-18T08:03:43ZLEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES1563-06252313-741X10.15789/1563-0625-2011-6-635-638https://doaj.org/article/2b897c3552bb49b5b21092d9de246afe2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/586https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We investigated effects of combined oral contraceptives (COC) containing low- and microdoses of estrogenic components upon serum levels of macroglobulin family proteins (alpha-2-macroglobulin, α2-MG, and pregnancy-associated alpha-2-glycoprotein, α2-PAG), their immune complexes with IgG, as well as concentrations of some cytokines (IL-1β, IL-6, TNFα, IFNγ). It was shown that cytokine levels did not differ with control, whereas α2-MG concentrations showed a time-dependent decrease in a group of women taking COC with microdoses of estrogens, and α2-PAG levels increased tenfold, independent on dosage and time of COC application. Meanwhile, contents of PAG-IgG complexes exhibits a gradual decrease, along with increase in MG-IgG. Considering PAG as a marker of normal and malignant proliferation, we suggest, that the levels of α2-PAG may be useful in monitoring of women taking COC, in order to predict high risk of pathological proliferation by evaluation of individuals with elevated α2-PAG levels. (Med. Immunol., 2011, vol. 13, N 6, pp 635-638)V. N. ZorinaE. V. KeremetskayaL. G. BagenovaR. M. ZorinaSPb RAACIarticlecombined oral contraceptivesmalignant proliferation riskalpha-2-macroglobulinpregnancy-associated alpha-2-glycoproteincytokinesimmune complexesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 6, Pp 635-638 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	combined oral contraceptives malignant proliferation risk alpha-2-macroglobulin pregnancy-associated alpha-2-glycoprotein cytokines immune complexes Immunologic diseases. Allergy RC581-607
spellingShingle	combined oral contraceptives malignant proliferation risk alpha-2-macroglobulin pregnancy-associated alpha-2-glycoprotein cytokines immune complexes Immunologic diseases. Allergy RC581-607 V. N. Zorina E. V. Keremetskaya L. G. Bagenova R. M. Zorina LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
description	Abstract. We investigated effects of combined oral contraceptives (COC) containing low- and microdoses of estrogenic components upon serum levels of macroglobulin family proteins (alpha-2-macroglobulin, α2-MG, and pregnancy-associated alpha-2-glycoprotein, α2-PAG), their immune complexes with IgG, as well as concentrations of some cytokines (IL-1β, IL-6, TNFα, IFNγ). It was shown that cytokine levels did not differ with control, whereas α2-MG concentrations showed a time-dependent decrease in a group of women taking COC with microdoses of estrogens, and α2-PAG levels increased tenfold, independent on dosage and time of COC application. Meanwhile, contents of PAG-IgG complexes exhibits a gradual decrease, along with increase in MG-IgG. Considering PAG as a marker of normal and malignant proliferation, we suggest, that the levels of α2-PAG may be useful in monitoring of women taking COC, in order to predict high risk of pathological proliferation by evaluation of individuals with elevated α2-PAG levels. (Med. Immunol., 2011, vol. 13, N 6, pp 635-638)
format	article
author	V. N. Zorina E. V. Keremetskaya L. G. Bagenova R. M. Zorina
author_facet	V. N. Zorina E. V. Keremetskaya L. G. Bagenova R. M. Zorina
author_sort	V. N. Zorina
title	LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
title_short	LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
title_full	LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
title_fullStr	LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
title_full_unstemmed	LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
title_sort	levels of key cytokines, macroglobulins and their specific immune complexes in blood sera of women taking combined oral contraceptives
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/2b897c3552bb49b5b21092d9de246afe
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LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES

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