p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system.
<h4>Background</h4>The p53 tumor suppressor, which is altered in most cancers, is a sequence-specific transcription factor that is able to modulate the expression of many target genes and influence a variety of cellular pathways. Inactivation of the p53 pathway in cancer frequently occur...
Guardado en:
Autores principales: | Virginia Andreotti, Yari Ciribilli, Paola Monti, Alessandra Bisio, Mattia Lion, Jennifer Jordan, Gilberto Fronza, Paola Menichini, Michael A Resnick, Alberto Inga |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2011
|
Materias: | |
Acceso en línea: | https://doaj.org/article/2b8a025dfb6a4609b60f93c77cb8b8e6 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound.
por: Yari Ciribilli, et al.
Publicado: (2010) -
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
por: Sinem Usluer, et al.
Publicado: (2021) -
Development of a novel immunoassay to detect interactions with the transactivation domain of p53: application to screening of new drugs
por: Yufeng Xiong, et al.
Publicado: (2017) -
Single-molecule analysis of steroid receptor and cofactor action in living cells
por: Ville Paakinaho, et al.
Publicado: (2017) -
Insights into Hydrocarbon Formation by Nitrogenase Cofactor Homologs
por: Chi Chung Lee, et al.
Publicado: (2015)