Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?

Abstract Background Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO. Methods We conducted a retrospe...

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Autores principales:	Zhimeng Wang, Qiang Huang, Lu Liu, Yao Lu, Congming Zhang, Teng Ma, Zhong Li, Qian Wang, Hanzhong Xue, Kun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Tranexamic acid Blood loss High tibial osteotomy Simultaneous bilateral Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/2b8c178662cf41ef982457c5c891d0b7
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spelling	oai:doaj.org-article:2b8c178662cf41ef982457c5c891d0b72021-11-14T12:28:32ZDose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?10.1186/s12891-021-04831-31471-2474https://doaj.org/article/2b8c178662cf41ef982457c5c891d0b72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12891-021-04831-3https://doaj.org/toc/1471-2474Abstract Background Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO. Methods We conducted a retrospective case–control study including 54 patients who underwent SBDTT-HTO. The single-dose group (n = 18) received 1 g of intravenous TXA 15–30 min before surgery, the two-dose group (n = 18) received an additional 1 g of intravenous TXA 6 h after surgery, and the multiple-dose group (n = 18) received an additional 1 g intravenous TXA per-day until discharge. Blood loss, hemoglobin levels, occurrence of any adverse events,functional analysis, quality of life, and pain assessmentswere compared among the three groups. Results The total blood loss, hidden blood loss, drainage volumes, and haemoglobin level in the multiple-dose group all occupy a significant advantage.(p < 0.05). In addition, better quality of life were observed in patients belonging to the multiple-dose group then single-dose group.(p < 0.05). Conclusions Based on our results, for patients undergoing SBDTT-HTO, sequential intravenous TXA administration can effectively and safely reduce blood loss,maintain postoperative Hb levels,and with the advantage of accelerating recovery.Zhimeng WangQiang HuangLu LiuYao LuCongming ZhangTeng MaZhong LiQian WangHanzhong XueKun ZhangBMCarticleTranexamic acidBlood lossHigh tibial osteotomySimultaneous bilateralDiseases of the musculoskeletal systemRC925-935ENBMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tranexamic acid Blood loss High tibial osteotomy Simultaneous bilateral Diseases of the musculoskeletal system RC925-935
spellingShingle	Tranexamic acid Blood loss High tibial osteotomy Simultaneous bilateral Diseases of the musculoskeletal system RC925-935 Zhimeng Wang Qiang Huang Lu Liu Yao Lu Congming Zhang Teng Ma Zhong Li Qian Wang Hanzhong Xue Kun Zhang Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
description	Abstract Background Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO. Methods We conducted a retrospective case–control study including 54 patients who underwent SBDTT-HTO. The single-dose group (n = 18) received 1 g of intravenous TXA 15–30 min before surgery, the two-dose group (n = 18) received an additional 1 g of intravenous TXA 6 h after surgery, and the multiple-dose group (n = 18) received an additional 1 g intravenous TXA per-day until discharge. Blood loss, hemoglobin levels, occurrence of any adverse events,functional analysis, quality of life, and pain assessmentswere compared among the three groups. Results The total blood loss, hidden blood loss, drainage volumes, and haemoglobin level in the multiple-dose group all occupy a significant advantage.(p < 0.05). In addition, better quality of life were observed in patients belonging to the multiple-dose group then single-dose group.(p < 0.05). Conclusions Based on our results, for patients undergoing SBDTT-HTO, sequential intravenous TXA administration can effectively and safely reduce blood loss,maintain postoperative Hb levels,and with the advantage of accelerating recovery.
format	article
author	Zhimeng Wang Qiang Huang Lu Liu Yao Lu Congming Zhang Teng Ma Zhong Li Qian Wang Hanzhong Xue Kun Zhang
author_facet	Zhimeng Wang Qiang Huang Lu Liu Yao Lu Congming Zhang Teng Ma Zhong Li Qian Wang Hanzhong Xue Kun Zhang
author_sort	Zhimeng Wang
title	Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
title_short	Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
title_full	Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
title_fullStr	Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
title_full_unstemmed	Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
title_sort	dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
publisher	BMC
publishDate	2021
url	https://doaj.org/article/2b8c178662cf41ef982457c5c891d0b7
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Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?

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