Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites

The article presents the research results of immunogenic potency of antigen preparation Bacillus anthracis Sterne 34F on the guinea pig model. It was found that a single inoculation of this preparation, before the contamination of virulent B. anthracis strain, protects 60-80 % of experimental animal...

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Autores principales:	V. I. Dubrovina, T. A. Ivanova, S. V. Lukyanova, O. V. Yuryeva, S. A. Vityazeva, O. B. Kolesnikova, V. B. Nikolayev, S. V. Balakhonov, V. E. Takaishvili
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	bacillus anthracis antigen nanocomposite immunogenicity Science Q
Acceso en línea:	https://doaj.org/article/2b8c601b1d844b2aabe1d4bb1fa3705f
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spelling	oai:doaj.org-article:2b8c601b1d844b2aabe1d4bb1fa3705f2021-11-23T06:14:32ZImmunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites2541-94202587-9596https://doaj.org/article/2b8c601b1d844b2aabe1d4bb1fa3705f2015-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/67https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the research results of immunogenic potency of antigen preparation Bacillus anthracis Sterne 34F on the guinea pig model. It was found that a single inoculation of this preparation, before the contamination of virulent B. anthracis strain, protects 60-80 % of experimental animals. The metal-containing nanocomposites were used to improve the immunogenicity of this antigen preparation. The combined use of antigenic preparation S-2 with argentogalactomannan increases its immunogenic potency and conduces to the survival of experimental animals. Argentogalactomannan exhibits adjuvant properties enhanced the immunogenic features of the S-2 B. anthracis 34F2 Sterne that may indicate its availability as an adjuvant in the construction of chemical vaccines.V. I. DubrovinaT. A. IvanovaS. V. LukyanovaO. V. YuryevaS. A. VityazevaO. B. KolesnikovaV. B. NikolayevS. V. BalakhonovV. E. TakaishviliScientific Сentre for Family Health and Human Reproduction Problemsarticlebacillus anthracisantigennanocompositeimmunogenicityScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3, Pp 33-37 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	bacillus anthracis antigen nanocomposite immunogenicity Science Q
spellingShingle	bacillus anthracis antigen nanocomposite immunogenicity Science Q V. I. Dubrovina T. A. Ivanova S. V. Lukyanova O. V. Yuryeva S. A. Vityazeva O. B. Kolesnikova V. B. Nikolayev S. V. Balakhonov V. E. Takaishvili Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites
description	The article presents the research results of immunogenic potency of antigen preparation Bacillus anthracis Sterne 34F on the guinea pig model. It was found that a single inoculation of this preparation, before the contamination of virulent B. anthracis strain, protects 60-80 % of experimental animals. The metal-containing nanocomposites were used to improve the immunogenicity of this antigen preparation. The combined use of antigenic preparation S-2 with argentogalactomannan increases its immunogenic potency and conduces to the survival of experimental animals. Argentogalactomannan exhibits adjuvant properties enhanced the immunogenic features of the S-2 B. anthracis 34F2 Sterne that may indicate its availability as an adjuvant in the construction of chemical vaccines.
format	article
author	V. I. Dubrovina T. A. Ivanova S. V. Lukyanova O. V. Yuryeva S. A. Vityazeva O. B. Kolesnikova V. B. Nikolayev S. V. Balakhonov V. E. Takaishvili
author_facet	V. I. Dubrovina T. A. Ivanova S. V. Lukyanova O. V. Yuryeva S. A. Vityazeva O. B. Kolesnikova V. B. Nikolayev S. V. Balakhonov V. E. Takaishvili
author_sort	V. I. Dubrovina
title	Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites
title_short	Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites
title_full	Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites
title_fullStr	Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites
title_full_unstemmed	Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites
title_sort	immunogenic potency of antigenic preparation bacillus anthracis sterne 34f<sub>2</sub> and its combination with metal-containing nanocomposites
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/2b8c601b1d844b2aabe1d4bb1fa3705f
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Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites

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