A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation

Abstract Epidemiological studies have shown a strong correlation between tumor and AF. However, the molecular link between tumor and AF remains unknown. ECRG4, a tumor suppressor gene that is expressed in the A-V node and in sporadic ventricular myocytes, inhibits tumorigenesis and monitors tissue h...

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Autores principales:	Li Huang, Hua Yu, Xinrong Fan, Xue Li, Liang Mao, Jun Cheng, Xiaorong Zeng, Xitong Dang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b8e3b7feb23479db72e32101f22a330
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spelling	oai:doaj.org-article:2b8e3b7feb23479db72e32101f22a3302021-12-02T15:05:03ZA Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation10.1038/s41598-017-02902-x2045-2322https://doaj.org/article/2b8e3b7feb23479db72e32101f22a3302017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02902-xhttps://doaj.org/toc/2045-2322Abstract Epidemiological studies have shown a strong correlation between tumor and AF. However, the molecular link between tumor and AF remains unknown. ECRG4, a tumor suppressor gene that is expressed in the A-V node and in sporadic ventricular myocytes, inhibits tumorigenesis and monitors tissue homeostasis by functioning as a ‘sentinel’ molecule gauging inflammatory and cell proliferative responses. To explore the potential physiological function of Ecrg4 in heart, we evaluated its distribution in heart, analyzed its expression in patients with persistent AF and in a canine AF model, and dissected the molecular events downstream of Ecrg4. The results showed that the level of Ecrg4 expression is homogenously high in atria and the conduction systems and in sporadic ventricular myocytes. Importantly, the expression of Ecrg4 was significantly decreased in atrial appendages of AF patients than patients with SR. Moreover, in rapid pacing canine AF models, the expression of ECRG4 in atria was significantly decreased compared to that of the controls. Mechanistically, knockdown ECRG4 in atrial myocytes significantly shortened the APDs, inhibited the expression of Gja1, and activated pro-inflammatory cascades and genes involved in cardiac remodeling. These results suggest that Ecrg4 may play a critical role in the pathogenesis of AF.Li HuangHua YuXinrong FanXue LiLiang MaoJun ChengXiaorong ZengXitong DangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Li Huang Hua Yu Xinrong Fan Xue Li Liang Mao Jun Cheng Xiaorong Zeng Xitong Dang A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation
description	Abstract Epidemiological studies have shown a strong correlation between tumor and AF. However, the molecular link between tumor and AF remains unknown. ECRG4, a tumor suppressor gene that is expressed in the A-V node and in sporadic ventricular myocytes, inhibits tumorigenesis and monitors tissue homeostasis by functioning as a ‘sentinel’ molecule gauging inflammatory and cell proliferative responses. To explore the potential physiological function of Ecrg4 in heart, we evaluated its distribution in heart, analyzed its expression in patients with persistent AF and in a canine AF model, and dissected the molecular events downstream of Ecrg4. The results showed that the level of Ecrg4 expression is homogenously high in atria and the conduction systems and in sporadic ventricular myocytes. Importantly, the expression of Ecrg4 was significantly decreased in atrial appendages of AF patients than patients with SR. Moreover, in rapid pacing canine AF models, the expression of ECRG4 in atria was significantly decreased compared to that of the controls. Mechanistically, knockdown ECRG4 in atrial myocytes significantly shortened the APDs, inhibited the expression of Gja1, and activated pro-inflammatory cascades and genes involved in cardiac remodeling. These results suggest that Ecrg4 may play a critical role in the pathogenesis of AF.
format	article
author	Li Huang Hua Yu Xinrong Fan Xue Li Liang Mao Jun Cheng Xiaorong Zeng Xitong Dang
author_facet	Li Huang Hua Yu Xinrong Fan Xue Li Liang Mao Jun Cheng Xiaorong Zeng Xitong Dang
author_sort	Li Huang
title	A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation
title_short	A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation
title_full	A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation
title_fullStr	A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation
title_full_unstemmed	A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation
title_sort	potential role of esophageal cancer related gene-4 for atrial fibrillation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2b8e3b7feb23479db72e32101f22a330
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A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation

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