Rosette nanotubes show low acute pulmonary toxicity in vivo

W Shane Journeay1, Sarabjeet S Suri1, Jesus G Moralez2, Hicham Fenniri2, Baljit Singh11Immunology Research Group, Toxicology Graduate Program and Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	W Shane Journeay, Sarabjeet S Suri, Jesus G Moralez, Hicham Fenniri, Baljit Singh
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2b8e3e87295442b9891b93ecf8344a3d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2b8e3e87295442b9891b93ecf8344a3d
record_format	dspace
spelling	oai:doaj.org-article:2b8e3e87295442b9891b93ecf8344a3d2021-12-02T03:11:38ZRosette nanotubes show low acute pulmonary toxicity in vivo1176-91141178-2013https://doaj.org/article/2b8e3e87295442b9891b93ecf8344a3d2008-10-01T00:00:00Zhttp://www.dovepress.com/rosette-nanotubes-show-low-acute-pulmonary-toxicity-emin-vivoem-a2437https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013W Shane Journeay1, Sarabjeet S Suri1, Jesus G Moralez2, Hicham Fenniri2, Baljit Singh11Immunology Research Group, Toxicology Graduate Program and Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada; 2National Institute of Nanotechnology, National Research Council (NINT-NRC) and Department of Chemistry, University of Alberta, 11421 Saskatchewan Drive, Edmonton, AB, T6G 2M9, CanadaAbstract: Nanotubes are being developed for a large variety of applications ranging from electronics to drug delivery. Common carbon nanotubes such as single-walled and multi-walled carbon nanotubes have been studied in the greatest detail but require solubilization and removal of catalytic contaminants such as metals prior to being introduced to biological systems for medical application. The present in vivo study characterizes the degree and nature of inflammation caused by a novel class of self-assembling rosette nanotubes, which are biologically inspired, naturally water-soluble and free of metal content upon synthesis. Upon pulmonary administration of this material we examined responses at 24 h and 7d post-exposure. An acute inflammatory response is triggered at 50 and 25 &mu;g doses by 24 h post-exposure but an inflammatory response is not triggered by a 5 &mu;g dose. Lung inflammation observed at a 50 &mu;g dose at 24 h was resolving by 7d. This work suggests that novel nanostructures with biological design may negate toxicity concerns for biomedical applications of nanotubes. This study also demonstrates that water-soluble rosette nanotube structures represent low pulmonary toxicity, likely due to their biologically inspired design, and their self-assembled architecture.Keywords: nanotoxicology, biocompatibility, nanomedicine, pulmonary drug delivery, lung inflammation W Shane JourneaySarabjeet S SuriJesus G MoralezHicham FenniriBaljit SinghDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 3, Pp 373-383 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 W Shane Journeay Sarabjeet S Suri Jesus G Moralez Hicham Fenniri Baljit Singh Rosette nanotubes show low acute pulmonary toxicity in vivo
description	W Shane Journeay1, Sarabjeet S Suri1, Jesus G Moralez2, Hicham Fenniri2, Baljit Singh11Immunology Research Group, Toxicology Graduate Program and Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada; 2National Institute of Nanotechnology, National Research Council (NINT-NRC) and Department of Chemistry, University of Alberta, 11421 Saskatchewan Drive, Edmonton, AB, T6G 2M9, CanadaAbstract: Nanotubes are being developed for a large variety of applications ranging from electronics to drug delivery. Common carbon nanotubes such as single-walled and multi-walled carbon nanotubes have been studied in the greatest detail but require solubilization and removal of catalytic contaminants such as metals prior to being introduced to biological systems for medical application. The present in vivo study characterizes the degree and nature of inflammation caused by a novel class of self-assembling rosette nanotubes, which are biologically inspired, naturally water-soluble and free of metal content upon synthesis. Upon pulmonary administration of this material we examined responses at 24 h and 7d post-exposure. An acute inflammatory response is triggered at 50 and 25 &mu;g doses by 24 h post-exposure but an inflammatory response is not triggered by a 5 &mu;g dose. Lung inflammation observed at a 50 &mu;g dose at 24 h was resolving by 7d. This work suggests that novel nanostructures with biological design may negate toxicity concerns for biomedical applications of nanotubes. This study also demonstrates that water-soluble rosette nanotube structures represent low pulmonary toxicity, likely due to their biologically inspired design, and their self-assembled architecture.Keywords: nanotoxicology, biocompatibility, nanomedicine, pulmonary drug delivery, lung inflammation
format	article
author	W Shane Journeay Sarabjeet S Suri Jesus G Moralez Hicham Fenniri Baljit Singh
author_facet	W Shane Journeay Sarabjeet S Suri Jesus G Moralez Hicham Fenniri Baljit Singh
author_sort	W Shane Journeay
title	Rosette nanotubes show low acute pulmonary toxicity in vivo
title_short	Rosette nanotubes show low acute pulmonary toxicity in vivo
title_full	Rosette nanotubes show low acute pulmonary toxicity in vivo
title_fullStr	Rosette nanotubes show low acute pulmonary toxicity in vivo
title_full_unstemmed	Rosette nanotubes show low acute pulmonary toxicity in vivo
title_sort	rosette nanotubes show low acute pulmonary toxicity in vivo
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/2b8e3e87295442b9891b93ecf8344a3d
work_keys_str_mv	AT wshanejourneay rosettenanotubesshowlowacutepulmonarytoxicityinvivo AT sarabjeetssuri rosettenanotubesshowlowacutepulmonarytoxicityinvivo AT jesusgmoralez rosettenanotubesshowlowacutepulmonarytoxicityinvivo AT hichamfenniri rosettenanotubesshowlowacutepulmonarytoxicityinvivo AT baljitsingh rosettenanotubesshowlowacutepulmonarytoxicityinvivo
_version_	1718401907536429056

Rosette nanotubes show low acute pulmonary toxicity in vivo

Ejemplares similares