Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer
Maroni, Bassal, Krishnan et al. characterise human non-small cell lung cancer (NSCLC) carrying Kras-mutations by single-cell RNA sequencing. They identify a tumour-specific population that is conserved in mice and responds to the drug, PTC596, which is currently in clinical trials and may offer a po...
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Nature Portfolio
2021
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oai:doaj.org-article:2b905167a9874951ba0ccb3de93359722021-12-02T15:51:05ZIdentification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer10.1038/s42003-021-01897-62399-3642https://doaj.org/article/2b905167a9874951ba0ccb3de93359722021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01897-6https://doaj.org/toc/2399-3642Maroni, Bassal, Krishnan et al. characterise human non-small cell lung cancer (NSCLC) carrying Kras-mutations by single-cell RNA sequencing. They identify a tumour-specific population that is conserved in mice and responds to the drug, PTC596, which is currently in clinical trials and may offer a potential avenue for treating aggressive NSCLC expressing mutated Kras.Giorgia MaroniMahmoud A. BassalIndira KrishnanChee Wai FhuVirginia SavovaRapolas ZilionisValerie A. MaymiNicole PandellEva CsizmadiaJunyan ZhangBarbara StortiJulio CastañoRiccardo PanellaJia LiCorinne E. GustafsonSam FoxRachel D. LevyClaire V. MeyerovitzPeter J. TramontozziKimberly VermilyaAssunta De RienzoStefania CrucittaDaniela S. BassèresMarla WeetallArt BranstromAlessandra GiorgettiRaffaele CiampiMarzia Del ReRomano DanesiRanieri BizzarriHenry YangOlivier KocherAllon M. KleinRobert S. WelnerRaphael BuenoMaria Cristina MagliJohn G. ClohessyAzhar AliDaniel G. TenenElena LevantiniNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Giorgia Maroni Mahmoud A. Bassal Indira Krishnan Chee Wai Fhu Virginia Savova Rapolas Zilionis Valerie A. Maymi Nicole Pandell Eva Csizmadia Junyan Zhang Barbara Storti Julio Castaño Riccardo Panella Jia Li Corinne E. Gustafson Sam Fox Rachel D. Levy Claire V. Meyerovitz Peter J. Tramontozzi Kimberly Vermilya Assunta De Rienzo Stefania Crucitta Daniela S. Bassères Marla Weetall Art Branstrom Alessandra Giorgetti Raffaele Ciampi Marzia Del Re Romano Danesi Ranieri Bizzarri Henry Yang Olivier Kocher Allon M. Klein Robert S. Welner Raphael Bueno Maria Cristina Magli John G. Clohessy Azhar Ali Daniel G. Tenen Elena Levantini Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer |
| description |
Maroni, Bassal, Krishnan et al. characterise human non-small cell lung cancer (NSCLC) carrying Kras-mutations by single-cell RNA sequencing. They identify a tumour-specific population that is conserved in mice and responds to the drug, PTC596, which is currently in clinical trials and may offer a potential avenue for treating aggressive NSCLC expressing mutated Kras. |
| format |
article |
| author |
Giorgia Maroni Mahmoud A. Bassal Indira Krishnan Chee Wai Fhu Virginia Savova Rapolas Zilionis Valerie A. Maymi Nicole Pandell Eva Csizmadia Junyan Zhang Barbara Storti Julio Castaño Riccardo Panella Jia Li Corinne E. Gustafson Sam Fox Rachel D. Levy Claire V. Meyerovitz Peter J. Tramontozzi Kimberly Vermilya Assunta De Rienzo Stefania Crucitta Daniela S. Bassères Marla Weetall Art Branstrom Alessandra Giorgetti Raffaele Ciampi Marzia Del Re Romano Danesi Ranieri Bizzarri Henry Yang Olivier Kocher Allon M. Klein Robert S. Welner Raphael Bueno Maria Cristina Magli John G. Clohessy Azhar Ali Daniel G. Tenen Elena Levantini |
| author_facet |
Giorgia Maroni Mahmoud A. Bassal Indira Krishnan Chee Wai Fhu Virginia Savova Rapolas Zilionis Valerie A. Maymi Nicole Pandell Eva Csizmadia Junyan Zhang Barbara Storti Julio Castaño Riccardo Panella Jia Li Corinne E. Gustafson Sam Fox Rachel D. Levy Claire V. Meyerovitz Peter J. Tramontozzi Kimberly Vermilya Assunta De Rienzo Stefania Crucitta Daniela S. Bassères Marla Weetall Art Branstrom Alessandra Giorgetti Raffaele Ciampi Marzia Del Re Romano Danesi Ranieri Bizzarri Henry Yang Olivier Kocher Allon M. Klein Robert S. Welner Raphael Bueno Maria Cristina Magli John G. Clohessy Azhar Ali Daniel G. Tenen Elena Levantini |
| author_sort |
Giorgia Maroni |
| title |
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer |
| title_short |
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer |
| title_full |
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer |
| title_fullStr |
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer |
| title_full_unstemmed |
Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer |
| title_sort |
identification of a targetable kras-mutant epithelial population in non-small cell lung cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2b905167a9874951ba0ccb3de9335972 |
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