Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma

There is a consensus that central compartment lymph node dissection or modified radical lateral neck dissection should be performed in papillary thyroid microcarcinoma (PTMC) patients with lymph node metastases. Prophylactic central lymph node dissection (PCLND) in patients with clinically node-nega...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peipei Yang, Jianming Li, Haoyu Jing, Qiyang Chen, Xinxin Song, Linxue Qian
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/2b935ba2458a4bc1abbe0c08731badf7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2b935ba2458a4bc1abbe0c08731badf7
record_format	dspace
spelling	oai:doaj.org-article:2b935ba2458a4bc1abbe0c08731badf72021-11-29T00:56:35ZEffect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma1687-834510.1155/2021/8270622https://doaj.org/article/2b935ba2458a4bc1abbe0c08731badf72021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8270622https://doaj.org/toc/1687-8345There is a consensus that central compartment lymph node dissection or modified radical lateral neck dissection should be performed in papillary thyroid microcarcinoma (PTMC) patients with lymph node metastases. Prophylactic central lymph node dissection (PCLND) in patients with clinically node-negative (cN0) PTMC to reduce locoregional recurrence (LRR) rate and improve prognosis remains controversial. The present study aimed to analyze the effect of PCLND on LRR and postoperative complications of PTMC in cN0 patients. We reviewed a cohort of patients with cN0 PTMC who underwent surgery between January 1997 and October 2019. The patients were divided into the PCLND and no lymph node dissection (NLND) groups. Kaplan–Meier curves were constructed to estimate 15-year locoregional recurrence-free survival rate of the two groups, and the difference was compared by the log-rank test. Three Cox regression models were performed to evaluate the correlation between PCLND and LRR. All patients underwent thyroidectomy, and 25 patients developed LRR; of whom, 23 underwent PCLND at initial surgery and 2 went without lymph node dissection. Cox regression analysis showed that PCLND had no effect on LRR. Postoperative hematoma and permanent recurrent laryngeal nerve injury did not occur in the NLND group, and their incidences were 0.5% and 0.3% in the PCLND group, respectively. PCLND had no significant correlation with LRR in patients with cN0 PTMC, and the absolute benefit for PTMC was small.Peipei YangJianming LiHaoyu JingQiyang ChenXinxin SongLinxue QianHindawi LimitedarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENInternational Journal of Endocrinology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diseases of the endocrine glands. Clinical endocrinology RC648-665 Peipei Yang Jianming Li Haoyu Jing Qiyang Chen Xinxin Song Linxue Qian Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma
description	There is a consensus that central compartment lymph node dissection or modified radical lateral neck dissection should be performed in papillary thyroid microcarcinoma (PTMC) patients with lymph node metastases. Prophylactic central lymph node dissection (PCLND) in patients with clinically node-negative (cN0) PTMC to reduce locoregional recurrence (LRR) rate and improve prognosis remains controversial. The present study aimed to analyze the effect of PCLND on LRR and postoperative complications of PTMC in cN0 patients. We reviewed a cohort of patients with cN0 PTMC who underwent surgery between January 1997 and October 2019. The patients were divided into the PCLND and no lymph node dissection (NLND) groups. Kaplan–Meier curves were constructed to estimate 15-year locoregional recurrence-free survival rate of the two groups, and the difference was compared by the log-rank test. Three Cox regression models were performed to evaluate the correlation between PCLND and LRR. All patients underwent thyroidectomy, and 25 patients developed LRR; of whom, 23 underwent PCLND at initial surgery and 2 went without lymph node dissection. Cox regression analysis showed that PCLND had no effect on LRR. Postoperative hematoma and permanent recurrent laryngeal nerve injury did not occur in the NLND group, and their incidences were 0.5% and 0.3% in the PCLND group, respectively. PCLND had no significant correlation with LRR in patients with cN0 PTMC, and the absolute benefit for PTMC was small.
format	article
author	Peipei Yang Jianming Li Haoyu Jing Qiyang Chen Xinxin Song Linxue Qian
author_facet	Peipei Yang Jianming Li Haoyu Jing Qiyang Chen Xinxin Song Linxue Qian
author_sort	Peipei Yang
title	Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma
title_short	Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma
title_full	Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma
title_fullStr	Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma
title_full_unstemmed	Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma
title_sort	effect of prophylactic central lymph node dissection on locoregional recurrence in patients with papillary thyroid microcarcinoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/2b935ba2458a4bc1abbe0c08731badf7
work_keys_str_mv	AT peipeiyang effectofprophylacticcentrallymphnodedissectiononlocoregionalrecurrenceinpatientswithpapillarythyroidmicrocarcinoma AT jianmingli effectofprophylacticcentrallymphnodedissectiononlocoregionalrecurrenceinpatientswithpapillarythyroidmicrocarcinoma AT haoyujing effectofprophylacticcentrallymphnodedissectiononlocoregionalrecurrenceinpatientswithpapillarythyroidmicrocarcinoma AT qiyangchen effectofprophylacticcentrallymphnodedissectiononlocoregionalrecurrenceinpatientswithpapillarythyroidmicrocarcinoma AT xinxinsong effectofprophylacticcentrallymphnodedissectiononlocoregionalrecurrenceinpatientswithpapillarythyroidmicrocarcinoma AT linxueqian effectofprophylacticcentrallymphnodedissectiononlocoregionalrecurrenceinpatientswithpapillarythyroidmicrocarcinoma
_version_	1718407695082455040

Effect of Prophylactic Central Lymph Node Dissection on Locoregional Recurrence in Patients with Papillary Thyroid Microcarcinoma

Ejemplares similares