An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.

Early life events induce alterations in neural function in adulthood. Although rearing in an enriched environment (EE) has a great impact on behavioral development, the effects of enriched rearing on sociosexual behavior remain unclear. In this study, we investigated the effects of rearing in an EE...

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Autores principales:	Susumu Urakawa, Dai Mitsushima, Michito Shimozuru, Yasuo Sakuma, Yasuhiko Kondo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2b988b671ae5431e967e9df46703fcf5
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spelling	oai:doaj.org-article:2b988b671ae5431e967e9df46703fcf52021-11-18T08:33:42ZAn enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.1932-620310.1371/journal.pone.0087911https://doaj.org/article/2b988b671ae5431e967e9df46703fcf52014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24505330/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Early life events induce alterations in neural function in adulthood. Although rearing in an enriched environment (EE) has a great impact on behavioral development, the effects of enriched rearing on sociosexual behavior remain unclear. In this study, we investigated the effects of rearing in an EE on male copulatory behavior and its underlying neurobiological mechanisms in Wistar-Imamichi rats. Three-week-old, recently weaned rats were continuously subjected to a standard environment (SE) or an EE comprised of a large cage with several objects, such as toys, tunnels, ladders, and a running wheel. After 6 weeks, rats reared in an EE (EE rats) showed decreased sexual activity compared with rats reared in a SE (SE rats). This included a lower number of ejaculations and longer latencies in three consecutive copulatory tests. In addition, EE rats showed decreased emotional responsiveness and less locomotor behavior in an open field. In a runway test, on the other hand, sexual motivation toward receptive females in EE males was comparable to that of SE males. Furthermore, following exposure to a female, increases in serotonin levels in the nucleus accumbens and the striatum were significantly suppressed in EE males, whereas dopaminergic responses were similar between the groups. Female-exposure-induced increases in the levels of plasma corticosterone and testosterone were also suppressed in EE rats compared to SE rats. These data suggest that rearing in an EE decreases male copulatory behavior, and serotonin and hormonal regulating systems may regulate the differences in sociosexual interactions that result from distinct rearing environments.Susumu UrakawaDai MitsushimaMichito ShimozuruYasuo SakumaYasuhiko KondoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87911 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susumu Urakawa Dai Mitsushima Michito Shimozuru Yasuo Sakuma Yasuhiko Kondo An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.
description	Early life events induce alterations in neural function in adulthood. Although rearing in an enriched environment (EE) has a great impact on behavioral development, the effects of enriched rearing on sociosexual behavior remain unclear. In this study, we investigated the effects of rearing in an EE on male copulatory behavior and its underlying neurobiological mechanisms in Wistar-Imamichi rats. Three-week-old, recently weaned rats were continuously subjected to a standard environment (SE) or an EE comprised of a large cage with several objects, such as toys, tunnels, ladders, and a running wheel. After 6 weeks, rats reared in an EE (EE rats) showed decreased sexual activity compared with rats reared in a SE (SE rats). This included a lower number of ejaculations and longer latencies in three consecutive copulatory tests. In addition, EE rats showed decreased emotional responsiveness and less locomotor behavior in an open field. In a runway test, on the other hand, sexual motivation toward receptive females in EE males was comparable to that of SE males. Furthermore, following exposure to a female, increases in serotonin levels in the nucleus accumbens and the striatum were significantly suppressed in EE males, whereas dopaminergic responses were similar between the groups. Female-exposure-induced increases in the levels of plasma corticosterone and testosterone were also suppressed in EE rats compared to SE rats. These data suggest that rearing in an EE decreases male copulatory behavior, and serotonin and hormonal regulating systems may regulate the differences in sociosexual interactions that result from distinct rearing environments.
format	article
author	Susumu Urakawa Dai Mitsushima Michito Shimozuru Yasuo Sakuma Yasuhiko Kondo
author_facet	Susumu Urakawa Dai Mitsushima Michito Shimozuru Yasuo Sakuma Yasuhiko Kondo
author_sort	Susumu Urakawa
title	An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.
title_short	An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.
title_full	An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.
title_fullStr	An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.
title_full_unstemmed	An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.
title_sort	enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/2b988b671ae5431e967e9df46703fcf5
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An enriched rearing environment calms adult male rat sexual activity: implication for distinct serotonergic and hormonal responses to females.

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