Stem cell treatment for avascular necrosis of the femoral head: current perspectives

Matthew T Houdek,1 Cody C Wyles,2 John R Martin,1 Rafael J Sierra11Department of Orthopedic Surgery, 2School of Medicine, Mayo Clinic, Rochester, MN, USAAbstract: Avascular necrosis (AVN) of the femoral head is a progressive disease that predominantly affects younger patients. Although the exact pa...

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Autores principales:	Houdek MT, Wyles CC, Martin JR, Sierra RJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/2b9898b9889249f899a6083005287f6e
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spelling	oai:doaj.org-article:2b9898b9889249f899a6083005287f6e2021-12-02T09:06:59ZStem cell treatment for avascular necrosis of the femoral head: current perspectives1178-6957https://doaj.org/article/2b9898b9889249f899a6083005287f6e2014-04-01T00:00:00Zhttp://www.dovepress.com/stem-cell-treatment-for-avascular-necrosis-of-the-femoral-head-current-a16410https://doaj.org/toc/1178-6957 Matthew T Houdek,1 Cody C Wyles,2 John R Martin,1 Rafael J Sierra11Department of Orthopedic Surgery, 2School of Medicine, Mayo Clinic, Rochester, MN, USAAbstract: Avascular necrosis (AVN) of the femoral head is a progressive disease that predominantly affects younger patients. Although the exact pathophysiology of AVN has yet to be elucidated, the disease is characterized by a vascular insult to the blood supply of the femoral head, which can lead to collapse of the femoral head and subsequent degenerative changes. If AVN is diagnosed in the early stages of the disease, it may be possible to attempt surgical procedures which preserve the hip joint, including decompression of the femoral head augmented with concentrated bone marrow. The use of autologous stem cells has shown promise in halting the progression of AVN of the femoral head, and subsequently preventing young patients from undergoing total hip arthroplasty. The purpose of this study was to review the current use of stem cells for the treatment of AVN of the femoral head.Keywords: avascular necrosis, femoral head, osteonecrosis, stem cells, concentrated bone marrowHoudek MTWyles CCMartin JRSierra RJDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2014, Iss default, Pp 65-70 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Houdek MT Wyles CC Martin JR Sierra RJ Stem cell treatment for avascular necrosis of the femoral head: current perspectives
description	Matthew T Houdek,1 Cody C Wyles,2 John R Martin,1 Rafael J Sierra11Department of Orthopedic Surgery, 2School of Medicine, Mayo Clinic, Rochester, MN, USAAbstract: Avascular necrosis (AVN) of the femoral head is a progressive disease that predominantly affects younger patients. Although the exact pathophysiology of AVN has yet to be elucidated, the disease is characterized by a vascular insult to the blood supply of the femoral head, which can lead to collapse of the femoral head and subsequent degenerative changes. If AVN is diagnosed in the early stages of the disease, it may be possible to attempt surgical procedures which preserve the hip joint, including decompression of the femoral head augmented with concentrated bone marrow. The use of autologous stem cells has shown promise in halting the progression of AVN of the femoral head, and subsequently preventing young patients from undergoing total hip arthroplasty. The purpose of this study was to review the current use of stem cells for the treatment of AVN of the femoral head.Keywords: avascular necrosis, femoral head, osteonecrosis, stem cells, concentrated bone marrow
format	article
author	Houdek MT Wyles CC Martin JR Sierra RJ
author_facet	Houdek MT Wyles CC Martin JR Sierra RJ
author_sort	Houdek MT
title	Stem cell treatment for avascular necrosis of the femoral head: current perspectives
title_short	Stem cell treatment for avascular necrosis of the femoral head: current perspectives
title_full	Stem cell treatment for avascular necrosis of the femoral head: current perspectives
title_fullStr	Stem cell treatment for avascular necrosis of the femoral head: current perspectives
title_full_unstemmed	Stem cell treatment for avascular necrosis of the femoral head: current perspectives
title_sort	stem cell treatment for avascular necrosis of the femoral head: current perspectives
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/2b9898b9889249f899a6083005287f6e
work_keys_str_mv	AT houdekmt stemcelltreatmentforavascularnecrosisofthefemoralheadcurrentperspectives AT wylescc stemcelltreatmentforavascularnecrosisofthefemoralheadcurrentperspectives AT martinjr stemcelltreatmentforavascularnecrosisofthefemoralheadcurrentperspectives AT sierrarj stemcelltreatmentforavascularnecrosisofthefemoralheadcurrentperspectives
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Stem cell treatment for avascular necrosis of the femoral head: current perspectives

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