Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective

Jie Zhang,1,&ast; Jinghua Jiao,2,&ast; Meng Niu,3,&ast; Xiaotong Gao,4 Guisen Zhang,5 Honghua Yu,6,&ast; Xiaohong Yang,6 Lei Liu6,7 1Department of Ophthalmology, Weifang Eye Hospital, Weifang, 261041, People’s Republic of China; 2Department of Anesthesiology, Central Hospital, Shenya...

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Autores principales:	Zhang J, Jiao J, Niu M, Gao X, Zhang G, Yu H, Yang X, Liu L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nano-carrier nanomedicine ocular disease drug delivery system. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2b999292e822454c9fbc9211278e340f
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spelling	oai:doaj.org-article:2b999292e822454c9fbc9211278e340f2021-12-02T17:17:56ZTen Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective1178-2013https://doaj.org/article/2b999292e822454c9fbc9211278e340f2021-09-01T00:00:00Zhttps://www.dovepress.com/ten-years-of-knowledge-of-nano-carrier-based-drug-delivery-systems-in--peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Jie Zhang,1,&ast; Jinghua Jiao,2,&ast; Meng Niu,3,&ast; Xiaotong Gao,4 Guisen Zhang,5 Honghua Yu,6,&ast; Xiaohong Yang,6 Lei Liu6,7 1Department of Ophthalmology, Weifang Eye Hospital, Weifang, 261041, People’s Republic of China; 2Department of Anesthesiology, Central Hospital, Shenyang Medical College, Shenyang, 110024, People’s Republic of China; 3Department of Radiology, First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 4Department of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 5Department of Retina, Inner Mongolia Chaoju Eye Hospital, Hohhot, 010050, People’s Republic of China; 6Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences; School of Medicine, South China University of Technology, Guangzhou, 510120, People’s Republic of China; 7Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaohong Yang; Lei Liu Email syyangxh@scut.edu.cn; liuleijiao@163.comAbstract: The complex drug delivery barrier in the eye reduces the bioavailability of many drugs, resulting in poor therapeutic effects. It is necessary to investigate new drugs through appropriate delivery routes and vehicles. Nanotechnology has utilized various nano-carriers to develop potential ocular drug delivery techniques that interact with the ocular mucosa, prolong the retention time of drugs in the eye, and increase permeability. Additionally, nano-carriers such as liposomes, nanoparticles, nano-suspensions, nano-micelles, and nano-emulsions have grown in popularity as an effective theranostic application to combat different microbial superbugs. In this review, we summarize the nano-carrier based drug delivery system developments over the last decade, particularly review the biology, methodology, approaches, and clinical applications of nano-carrier based drug delivery system in the field of ocular therapeutics. Furthermore, this review addresses upcoming challenges, and provides an outlook on potential future trends of nano-carrier-based drug delivery approaches in ophthalmology, and hopes to eventually provide successful applications for treating ocular diseases.Keywords: nano-carrier, nanomedicine, ocular disease, drug delivery systemZhang JJiao JNiu MGao XZhang GYu HYang XLiu LDove Medical Pressarticlenano-carriernanomedicineocular diseasedrug delivery system.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 6497-6530 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nano-carrier nanomedicine ocular disease drug delivery system. Medicine (General) R5-920
spellingShingle	nano-carrier nanomedicine ocular disease drug delivery system. Medicine (General) R5-920 Zhang J Jiao J Niu M Gao X Zhang G Yu H Yang X Liu L Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective
description	Jie Zhang,1,&ast; Jinghua Jiao,2,&ast; Meng Niu,3,&ast; Xiaotong Gao,4 Guisen Zhang,5 Honghua Yu,6,&ast; Xiaohong Yang,6 Lei Liu6,7 1Department of Ophthalmology, Weifang Eye Hospital, Weifang, 261041, People’s Republic of China; 2Department of Anesthesiology, Central Hospital, Shenyang Medical College, Shenyang, 110024, People’s Republic of China; 3Department of Radiology, First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 4Department of Endocrinology and Metabolism and the Institute of Endocrinology, The First Hospital of China Medical University, Shenyang, 110001, People’s Republic of China; 5Department of Retina, Inner Mongolia Chaoju Eye Hospital, Hohhot, 010050, People’s Republic of China; 6Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences; School of Medicine, South China University of Technology, Guangzhou, 510120, People’s Republic of China; 7Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaohong Yang; Lei Liu Email syyangxh@scut.edu.cn; liuleijiao@163.comAbstract: The complex drug delivery barrier in the eye reduces the bioavailability of many drugs, resulting in poor therapeutic effects. It is necessary to investigate new drugs through appropriate delivery routes and vehicles. Nanotechnology has utilized various nano-carriers to develop potential ocular drug delivery techniques that interact with the ocular mucosa, prolong the retention time of drugs in the eye, and increase permeability. Additionally, nano-carriers such as liposomes, nanoparticles, nano-suspensions, nano-micelles, and nano-emulsions have grown in popularity as an effective theranostic application to combat different microbial superbugs. In this review, we summarize the nano-carrier based drug delivery system developments over the last decade, particularly review the biology, methodology, approaches, and clinical applications of nano-carrier based drug delivery system in the field of ocular therapeutics. Furthermore, this review addresses upcoming challenges, and provides an outlook on potential future trends of nano-carrier-based drug delivery approaches in ophthalmology, and hopes to eventually provide successful applications for treating ocular diseases.Keywords: nano-carrier, nanomedicine, ocular disease, drug delivery system
format	article
author	Zhang J Jiao J Niu M Gao X Zhang G Yu H Yang X Liu L
author_facet	Zhang J Jiao J Niu M Gao X Zhang G Yu H Yang X Liu L
author_sort	Zhang J
title	Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective
title_short	Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective
title_full	Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective
title_fullStr	Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective
title_full_unstemmed	Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective
title_sort	ten years of knowledge of nano-carrier based drug delivery systems in ophthalmology: current evidence, challenges, and future prospective
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2b999292e822454c9fbc9211278e340f
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Ten Years of Knowledge of Nano-Carrier Based Drug Delivery Systems in Ophthalmology: Current Evidence, Challenges, and Future Prospective

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