Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats

The article presents the pathophysiological assessment of the results of atherogenic dyslipidemia simulation in Wistar rats. Dyslipidemia was followed by 24 % increase of triglyceride and 19 % raise of total cholesterol in blood, while the atherogenic cholesterol of low density lipoproteins increase...

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Autor principal:	V. G. Banzaraksheev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	atherogenic dyslipidemia lipid metabolism endothelial dysfunction Science Q
Acceso en línea:	https://doaj.org/article/2b9b3330071a45f88610bf5697f6c2ea
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spelling	oai:doaj.org-article:2b9b3330071a45f88610bf5697f6c2ea2021-11-23T06:14:34ZPathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats2541-94202587-959610.12737/21591https://doaj.org/article/2b9b3330071a45f88610bf5697f6c2ea2016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/222https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the pathophysiological assessment of the results of atherogenic dyslipidemia simulation in Wistar rats. Dyslipidemia was followed by 24 % increase of triglyceride and 19 % raise of total cholesterol in blood, while the atherogenic cholesterol of low density lipoproteins increased by 39 %, and the content of anti-atherogenic cholesterol of high density lipoproteins decreased by 21 %. Furthermore, the level of modified low density lipoproteins in the blood increased by 1.8 times. On the background of lipid storage disorder the rats of the experimental group showed the signs of endothelial dysfunction: circulating endothelial cell number increased by 1.9 times, proinflammatory cytokines interleukin-1beta (IL-1ß), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) increased by 21, 18 and 16 % respectively, high-sensitivity C-reactive protein (hsCRP) concentration - by 2.2 times, and fibrinogen concentration - by 17 %.V. G. BanzaraksheevScientific Сentre for Family Health and Human Reproduction Problemsarticleatherogenic dyslipidemialipid metabolismendothelial dysfunctionScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(1), Pp 33-36 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	atherogenic dyslipidemia lipid metabolism endothelial dysfunction Science Q
spellingShingle	atherogenic dyslipidemia lipid metabolism endothelial dysfunction Science Q V. G. Banzaraksheev Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
description	The article presents the pathophysiological assessment of the results of atherogenic dyslipidemia simulation in Wistar rats. Dyslipidemia was followed by 24 % increase of triglyceride and 19 % raise of total cholesterol in blood, while the atherogenic cholesterol of low density lipoproteins increased by 39 %, and the content of anti-atherogenic cholesterol of high density lipoproteins decreased by 21 %. Furthermore, the level of modified low density lipoproteins in the blood increased by 1.8 times. On the background of lipid storage disorder the rats of the experimental group showed the signs of endothelial dysfunction: circulating endothelial cell number increased by 1.9 times, proinflammatory cytokines interleukin-1beta (IL-1ß), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) increased by 21, 18 and 16 % respectively, high-sensitivity C-reactive protein (hsCRP) concentration - by 2.2 times, and fibrinogen concentration - by 17 %.
format	article
author	V. G. Banzaraksheev
author_facet	V. G. Banzaraksheev
author_sort	V. G. Banzaraksheev
title	Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
title_short	Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
title_full	Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
title_fullStr	Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
title_full_unstemmed	Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
title_sort	pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/2b9b3330071a45f88610bf5697f6c2ea
work_keys_str_mv	AT vgbanzaraksheev pathophysiologicalrationalefortheresultsofatherogenicdyslipidemiasimulationinrats
_version_	1718417059642081280

Pathophysiological rationale for the results of atherogenic dyslipidemia simulation in rats

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