A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

Individual human epidermal cells differ in their self-renewal ability. Here the authors perform genome-wide pooled RNAi screens to uncover the molecular basis for this heterogeneity, and identify genes conferring a clonal growth advantage on normal and neoplastic human epidermal cells.

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Bibliographic Details
Main Authors: Gernot Walko, Samuel Woodhouse, Angela Oliveira Pisco, Emanuel Rognoni, Kifayathullah Liakath-Ali, Beate M. Lichtenberger, Ajay Mishra, Stephanie B. Telerman, Priyalakshmi Viswanathan, Meike Logtenberg, Lisa M. Renz, Giacomo Donati, Sven R. Quist, Fiona M. Watt
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/2b9b9d9908ac4a09a7f10f863e934277
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Summary:Individual human epidermal cells differ in their self-renewal ability. Here the authors perform genome-wide pooled RNAi screens to uncover the molecular basis for this heterogeneity, and identify genes conferring a clonal growth advantage on normal and neoplastic human epidermal cells.

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