A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

Individual human epidermal cells differ in their self-renewal ability. Here the authors perform genome-wide pooled RNAi screens to uncover the molecular basis for this heterogeneity, and identify genes conferring a clonal growth advantage on normal and neoplastic human epidermal cells.

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Autores principales:	Gernot Walko, Samuel Woodhouse, Angela Oliveira Pisco, Emanuel Rognoni, Kifayathullah Liakath-Ali, Beate M. Lichtenberger, Ajay Mishra, Stephanie B. Telerman, Priyalakshmi Viswanathan, Meike Logtenberg, Lisa M. Renz, Giacomo Donati, Sven R. Quist, Fiona M. Watt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2b9b9d9908ac4a09a7f10f863e934277
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spelling	oai:doaj.org-article:2b9b9d9908ac4a09a7f10f863e9342772021-12-02T14:42:36ZA genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells10.1038/ncomms147442041-1723https://doaj.org/article/2b9b9d9908ac4a09a7f10f863e9342772017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14744https://doaj.org/toc/2041-1723Individual human epidermal cells differ in their self-renewal ability. Here the authors perform genome-wide pooled RNAi screens to uncover the molecular basis for this heterogeneity, and identify genes conferring a clonal growth advantage on normal and neoplastic human epidermal cells.Gernot WalkoSamuel WoodhouseAngela Oliveira PiscoEmanuel RognoniKifayathullah Liakath-AliBeate M. LichtenbergerAjay MishraStephanie B. TelermanPriyalakshmi ViswanathanMeike LogtenbergLisa M. RenzGiacomo DonatiSven R. QuistFiona M. WattNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gernot Walko Samuel Woodhouse Angela Oliveira Pisco Emanuel Rognoni Kifayathullah Liakath-Ali Beate M. Lichtenberger Ajay Mishra Stephanie B. Telerman Priyalakshmi Viswanathan Meike Logtenberg Lisa M. Renz Giacomo Donati Sven R. Quist Fiona M. Watt A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells
description	Individual human epidermal cells differ in their self-renewal ability. Here the authors perform genome-wide pooled RNAi screens to uncover the molecular basis for this heterogeneity, and identify genes conferring a clonal growth advantage on normal and neoplastic human epidermal cells.
format	article
author	Gernot Walko Samuel Woodhouse Angela Oliveira Pisco Emanuel Rognoni Kifayathullah Liakath-Ali Beate M. Lichtenberger Ajay Mishra Stephanie B. Telerman Priyalakshmi Viswanathan Meike Logtenberg Lisa M. Renz Giacomo Donati Sven R. Quist Fiona M. Watt
author_facet	Gernot Walko Samuel Woodhouse Angela Oliveira Pisco Emanuel Rognoni Kifayathullah Liakath-Ali Beate M. Lichtenberger Ajay Mishra Stephanie B. Telerman Priyalakshmi Viswanathan Meike Logtenberg Lisa M. Renz Giacomo Donati Sven R. Quist Fiona M. Watt
author_sort	Gernot Walko
title	A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells
title_short	A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells
title_full	A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells
title_fullStr	A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells
title_full_unstemmed	A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells
title_sort	genome-wide screen identifies yap/wbp2 interplay conferring growth advantage on human epidermal stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2b9b9d9908ac4a09a7f10f863e934277
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A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

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