A prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy.
<h4>Introduction</h4>Uterine leiomyoma (UL) is a common benign pelvic tumor in women that has a high recurrence rate. Our aim is to propose a prognostic index (PI) model for predicting the long-term recurrence risk of uterine leiomyoma (UL).<h4>Methods</h4>A total of 725 wome...
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2021
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oai:doaj.org-article:2b9d6dff6a234d9fbc5ff912cb85ddb42021-12-02T20:09:42ZA prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy.1932-620310.1371/journal.pone.0254142https://doaj.org/article/2b9d6dff6a234d9fbc5ff912cb85ddb42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254142https://doaj.org/toc/1932-6203<h4>Introduction</h4>Uterine leiomyoma (UL) is a common benign pelvic tumor in women that has a high recurrence rate. Our aim is to propose a prognostic index (PI) model for predicting the long-term recurrence risk of uterine leiomyoma (UL).<h4>Methods</h4>A total of 725 women who underwent myomectomy were enrolled in this retrospective multicenter study. Patients were contacted for follow-up. A PI model was proposed based on the multivariate Cox regression analysis in the model group. The predictive value of this model was tested in both internal and external validation group.<h4>Results</h4>PI formula = 1.5(if 3-5 leiomyomas) or 2(if >5 leiomyomas)+1(if residue)+1(if not submucosal)+1(if combined endometriosis). The PI value was divided into low-risk, intermediate-risk, and high-risk group by cut-off values 1.25 and 3.75. In the model group, the high-risk group had a significantly 4.55 times greater recurrence risk of UL than that in the low-risk group [cumulative recurrence rate (CR): 82.1% vs 29.5%, HR = 4.55, 95% CI 2.821-7.339]; the intermediate-risk group had a significantly 2.81 times greater recurrence risk of UL than that in the low-risk group (CR: 62.3% vs 29.5%, HR = 2.81, 95% CI 2.035-3.878). The differences between any two risk groups were also significant (P< 0.05) in both internal and external validation groups.<h4>Conclusion</h4>The model was proved to be effective in predicting recurrence of UL after myomectomy.Xiu MingJunying ZhouJinhai GouNa LiDan NieLuqi XueZhengyu LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254142 (2021) |
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Medicine R Science Q Xiu Ming Junying Zhou Jinhai Gou Na Li Dan Nie Luqi Xue Zhengyu Li A prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy. |
| description |
<h4>Introduction</h4>Uterine leiomyoma (UL) is a common benign pelvic tumor in women that has a high recurrence rate. Our aim is to propose a prognostic index (PI) model for predicting the long-term recurrence risk of uterine leiomyoma (UL).<h4>Methods</h4>A total of 725 women who underwent myomectomy were enrolled in this retrospective multicenter study. Patients were contacted for follow-up. A PI model was proposed based on the multivariate Cox regression analysis in the model group. The predictive value of this model was tested in both internal and external validation group.<h4>Results</h4>PI formula = 1.5(if 3-5 leiomyomas) or 2(if >5 leiomyomas)+1(if residue)+1(if not submucosal)+1(if combined endometriosis). The PI value was divided into low-risk, intermediate-risk, and high-risk group by cut-off values 1.25 and 3.75. In the model group, the high-risk group had a significantly 4.55 times greater recurrence risk of UL than that in the low-risk group [cumulative recurrence rate (CR): 82.1% vs 29.5%, HR = 4.55, 95% CI 2.821-7.339]; the intermediate-risk group had a significantly 2.81 times greater recurrence risk of UL than that in the low-risk group (CR: 62.3% vs 29.5%, HR = 2.81, 95% CI 2.035-3.878). The differences between any two risk groups were also significant (P< 0.05) in both internal and external validation groups.<h4>Conclusion</h4>The model was proved to be effective in predicting recurrence of UL after myomectomy. |
| format |
article |
| author |
Xiu Ming Junying Zhou Jinhai Gou Na Li Dan Nie Luqi Xue Zhengyu Li |
| author_facet |
Xiu Ming Junying Zhou Jinhai Gou Na Li Dan Nie Luqi Xue Zhengyu Li |
| author_sort |
Xiu Ming |
| title |
A prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy. |
| title_short |
A prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy. |
| title_full |
A prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy. |
| title_fullStr |
A prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy. |
| title_full_unstemmed |
A prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy. |
| title_sort |
prognostic index model for predicting long-term recurrence of uterine leiomyoma after myomectomy. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/2b9d6dff6a234d9fbc5ff912cb85ddb4 |
| work_keys_str_mv |
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1718375052153454592 |