Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men

Introduction: MiRNA expression alterations are closely related to growth, proliferation, and cell development. In addition, miR-187 has been found to regulate cellular proliferation. Further, spermatogenesis is a highly complicated process which is regulated through several genes targeted by miRNAs....

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Autores principales:	Fahimeh Piryaei, Hossein Mozdarani, Mohammad Ali Sadighi Gilani, Mansour Ebrahimi
Formato:	article
Lenguaje:	EN
Publicado:	Zabol University of Medical sciences 2020
Materias:	non-obstructive azoospermia (noa) obstructive azoospermia (oa) mir-187 sertoli cell only syndrome (scos) testicular tissue Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2ba056e26d644e8aa851cd5adf23a0ec
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spelling	oai:doaj.org-article:2ba056e26d644e8aa851cd5adf23a0ec2021-11-17T09:54:24ZHomo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men2476-664X10.34172/ijbsm.2020.08https://doaj.org/article/2ba056e26d644e8aa851cd5adf23a0ec2020-06-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-13314https://doaj.org/toc/2476-664XIntroduction: MiRNA expression alterations are closely related to growth, proliferation, and cell development. In addition, miR-187 has been found to regulate cellular proliferation. Further, spermatogenesis is a highly complicated process which is regulated through several genes targeted by miRNAs. However, no study has completely addressed the etiology of spermatogenic impairments. Accordingly, the present study examined the expression pattern of Homo sapiens (human) microRNA (hsa-mir-187) in the testicular biopsies of infertile men with non-obstructive azoospermia (NOA) and Sertoli cell-only syndrome (SCOS) subtype in comparison with those with obstructive azoospermia (OA). Methods: Quantitative reverse‐transcription polymerase chain reaction analysis was performed to assess the expression level of hsa-mir-187 using the ΔΔCt method. Results: Our data indicated that hsa-mir-187 was significantly up-regulated in the testis of the SCOS group (P˂ 0.05) in comparison with the OA group. Conclusion: In general, the findings suggest that the differential expression of hsa-mir-187 is linked with male infertility and shed more light on molecular defects that underlie spermatogenic impairments.Fahimeh PiryaeiHossein MozdaraniMohammad Ali Sadighi GilaniMansour EbrahimiZabol University of Medical sciencesarticlenon-obstructive azoospermia (noa) obstructive azoospermia (oa) mir-187 sertoli cell only syndrome (scos) testicular tissue Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 5, Iss 2, Pp 39-42 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-obstructive azoospermia (noa) obstructive azoospermia (oa) mir-187 sertoli cell only syndrome (scos) testicular tissue Medicine (General) R5-920
spellingShingle	non-obstructive azoospermia (noa) obstructive azoospermia (oa) mir-187 sertoli cell only syndrome (scos) testicular tissue Medicine (General) R5-920 Fahimeh Piryaei Hossein Mozdarani Mohammad Ali Sadighi Gilani Mansour Ebrahimi Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men
description	Introduction: MiRNA expression alterations are closely related to growth, proliferation, and cell development. In addition, miR-187 has been found to regulate cellular proliferation. Further, spermatogenesis is a highly complicated process which is regulated through several genes targeted by miRNAs. However, no study has completely addressed the etiology of spermatogenic impairments. Accordingly, the present study examined the expression pattern of Homo sapiens (human) microRNA (hsa-mir-187) in the testicular biopsies of infertile men with non-obstructive azoospermia (NOA) and Sertoli cell-only syndrome (SCOS) subtype in comparison with those with obstructive azoospermia (OA). Methods: Quantitative reverse‐transcription polymerase chain reaction analysis was performed to assess the expression level of hsa-mir-187 using the ΔΔCt method. Results: Our data indicated that hsa-mir-187 was significantly up-regulated in the testis of the SCOS group (P˂ 0.05) in comparison with the OA group. Conclusion: In general, the findings suggest that the differential expression of hsa-mir-187 is linked with male infertility and shed more light on molecular defects that underlie spermatogenic impairments.
format	article
author	Fahimeh Piryaei Hossein Mozdarani Mohammad Ali Sadighi Gilani Mansour Ebrahimi
author_facet	Fahimeh Piryaei Hossein Mozdarani Mohammad Ali Sadighi Gilani Mansour Ebrahimi
author_sort	Fahimeh Piryaei
title	Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men
title_short	Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men
title_full	Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men
title_fullStr	Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men
title_full_unstemmed	Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men
title_sort	homo sapiens (human) microrna 187 expression is dysregulated in testis of non-obstructive azoospermic men
publisher	Zabol University of Medical sciences
publishDate	2020
url	https://doaj.org/article/2ba056e26d644e8aa851cd5adf23a0ec
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Homo Sapiens (Human) microRNA 187 Expression Is Dysregulated in Testis of Non-obstructive Azoospermic Men

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