The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression

The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression

Myoblast fusion in skeletal muscle is a complex process but how this is regulated is unclear. Here, the authors identify Ash1L, a histone methyltransferase, as modulating myoblast fusion via activation of the myogenesis gene Cdon, and observe decreased Ash1L expression in Duchenne muscular dystrophy...

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Autores principales: Ilaria Castiglioni, Roberta Caccia, Jose Manuel Garcia-Manteiga, Giulia Ferri, Giuseppina Caretti, Ivan Molineris, Kenichi Nishioka, Davide Gabellini
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2ba6d0377f3f4bbb974cf9e23ced4e21
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spelling oai:doaj.org-article:2ba6d0377f3f4bbb974cf9e23ced4e212021-12-02T14:40:03ZThe Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression10.1038/s41467-018-07313-82041-1723https://doaj.org/article/2ba6d0377f3f4bbb974cf9e23ced4e212018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07313-8https://doaj.org/toc/2041-1723Myoblast fusion in skeletal muscle is a complex process but how this is regulated is unclear. Here, the authors identify Ash1L, a histone methyltransferase, as modulating myoblast fusion via activation of the myogenesis gene Cdon, and observe decreased Ash1L expression in Duchenne muscular dystrophy.Ilaria CastiglioniRoberta CacciaJose Manuel Garcia-ManteigaGiulia FerriGiuseppina CarettiIvan MolinerisKenichi NishiokaDavide GabelliniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ilaria Castiglioni
Roberta Caccia
Jose Manuel Garcia-Manteiga
Giulia Ferri
Giuseppina Caretti
Ivan Molineris
Kenichi Nishioka
Davide Gabellini
The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
description Myoblast fusion in skeletal muscle is a complex process but how this is regulated is unclear. Here, the authors identify Ash1L, a histone methyltransferase, as modulating myoblast fusion via activation of the myogenesis gene Cdon, and observe decreased Ash1L expression in Duchenne muscular dystrophy.
format article
author Ilaria Castiglioni
Roberta Caccia
Jose Manuel Garcia-Manteiga
Giulia Ferri
Giuseppina Caretti
Ivan Molineris
Kenichi Nishioka
Davide Gabellini
author_facet Ilaria Castiglioni
Roberta Caccia
Jose Manuel Garcia-Manteiga
Giulia Ferri
Giuseppina Caretti
Ivan Molineris
Kenichi Nishioka
Davide Gabellini
author_sort Ilaria Castiglioni
title The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
title_short The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
title_full The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
title_fullStr The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
title_full_unstemmed The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression
title_sort trithorax protein ash1l promotes myoblast fusion by activating cdon expression
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/2ba6d0377f3f4bbb974cf9e23ced4e21
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