The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression

Myoblast fusion in skeletal muscle is a complex process but how this is regulated is unclear. Here, the authors identify Ash1L, a histone methyltransferase, as modulating myoblast fusion via activation of the myogenesis gene Cdon, and observe decreased Ash1L expression in Duchenne muscular dystrophy...

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Main Authors: Ilaria Castiglioni, Roberta Caccia, Jose Manuel Garcia-Manteiga, Giulia Ferri, Giuseppina Caretti, Ivan Molineris, Kenichi Nishioka, Davide Gabellini
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/2ba6d0377f3f4bbb974cf9e23ced4e21
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