Critical role for arginase 2 in obesity-associated pancreatic cancer

Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor gr...

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Autores principales:	Tamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois, Elizaveta Freinkman, Lin Lin, Vicente Morales-Oyarvide, Patrick J. Lenehan, Brian M. Wolpin, Mari Mino-Kenudson, Eduardo M. Torres, Nicholas Stylopoulos, Clary B. Clish, Nada Y. Kalaany
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bac1b53384648ab8ef09add810f760d
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spelling	oai:doaj.org-article:2bac1b53384648ab8ef09add810f760d2021-12-02T13:24:14ZCritical role for arginase 2 in obesity-associated pancreatic cancer10.1038/s41467-017-00331-y2041-1723https://doaj.org/article/2bac1b53384648ab8ef09add810f760d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00331-yhttps://doaj.org/toc/2041-1723Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor growth.Tamara ZaytouniPei-Yun TsaiDaniel S. HitchcockCory D. DuBoisElizaveta FreinkmanLin LinVicente Morales-OyarvidePatrick J. LenehanBrian M. WolpinMari Mino-KenudsonEduardo M. TorresNicholas StylopoulosClary B. ClishNada Y. KalaanyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamara Zaytouni Pei-Yun Tsai Daniel S. Hitchcock Cory D. DuBois Elizaveta Freinkman Lin Lin Vicente Morales-Oyarvide Patrick J. Lenehan Brian M. Wolpin Mari Mino-Kenudson Eduardo M. Torres Nicholas Stylopoulos Clary B. Clish Nada Y. Kalaany Critical role for arginase 2 in obesity-associated pancreatic cancer
description	Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor growth.
format	article
author	Tamara Zaytouni Pei-Yun Tsai Daniel S. Hitchcock Cory D. DuBois Elizaveta Freinkman Lin Lin Vicente Morales-Oyarvide Patrick J. Lenehan Brian M. Wolpin Mari Mino-Kenudson Eduardo M. Torres Nicholas Stylopoulos Clary B. Clish Nada Y. Kalaany
author_facet	Tamara Zaytouni Pei-Yun Tsai Daniel S. Hitchcock Cory D. DuBois Elizaveta Freinkman Lin Lin Vicente Morales-Oyarvide Patrick J. Lenehan Brian M. Wolpin Mari Mino-Kenudson Eduardo M. Torres Nicholas Stylopoulos Clary B. Clish Nada Y. Kalaany
author_sort	Tamara Zaytouni
title	Critical role for arginase 2 in obesity-associated pancreatic cancer
title_short	Critical role for arginase 2 in obesity-associated pancreatic cancer
title_full	Critical role for arginase 2 in obesity-associated pancreatic cancer
title_fullStr	Critical role for arginase 2 in obesity-associated pancreatic cancer
title_full_unstemmed	Critical role for arginase 2 in obesity-associated pancreatic cancer
title_sort	critical role for arginase 2 in obesity-associated pancreatic cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2bac1b53384648ab8ef09add810f760d
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Critical role for arginase 2 in obesity-associated pancreatic cancer

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