Reducing infections through nanotechnology and nanoparticles

Erik Taylor1, Thomas J Webster1,21School of Engineering, 2Department of Orthopedics, Brown University, Providence, RI, USAAbstract: The expansion of bacterial antibiotic resistance is a growing problem today. When medical devices are inserted into the body, it becomes especially difficult for the bo...

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Autores principales:	Taylor E, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2bac7444e84c4f7b98eaa9df1381d529
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spelling	oai:doaj.org-article:2bac7444e84c4f7b98eaa9df1381d5292021-12-02T02:01:32ZReducing infections through nanotechnology and nanoparticles1176-91141178-2013https://doaj.org/article/2bac7444e84c4f7b98eaa9df1381d5292011-07-01T00:00:00Zhttp://www.dovepress.com/reducing-infections-through-nanotechnology-and-nanoparticles-a7869https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Erik Taylor1, Thomas J Webster1,21School of Engineering, 2Department of Orthopedics, Brown University, Providence, RI, USAAbstract: The expansion of bacterial antibiotic resistance is a growing problem today. When medical devices are inserted into the body, it becomes especially difficult for the body to clear robustly adherent antibiotic-resistant biofilm infections. In addition, concerns about the spread of bacterial genetic tolerance to antibiotics, such as that found in multiple drug-resistant Staphylococcus aureus (MRSA), have significantly increased of late. As a growing direction in biomaterial design, nanomaterials (materials with at least one dimension less than 100 nm) may potentially prevent bacterial functions that lead to infections. As a first step in this direction, various nanoparticles have been explored for improving bacteria and biofilm penetration, generating reactive oxygen species, and killing bacteria, potentially providing a novel method for fighting infections that is nondrug related. This review article will first examine in detail the mechanisms and applications of some of these nanoparticles, then follow with some recent material designs utilizing nanotechnology that are centered on fighting medical device infections.Keywords: nanomaterials, medical device infection, antibacterial, antibiotic resistance, nanoparticle, biofilms&nbsp;Taylor EWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1463-1473 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Taylor E Webster TJ Reducing infections through nanotechnology and nanoparticles
description	Erik Taylor1, Thomas J Webster1,21School of Engineering, 2Department of Orthopedics, Brown University, Providence, RI, USAAbstract: The expansion of bacterial antibiotic resistance is a growing problem today. When medical devices are inserted into the body, it becomes especially difficult for the body to clear robustly adherent antibiotic-resistant biofilm infections. In addition, concerns about the spread of bacterial genetic tolerance to antibiotics, such as that found in multiple drug-resistant Staphylococcus aureus (MRSA), have significantly increased of late. As a growing direction in biomaterial design, nanomaterials (materials with at least one dimension less than 100 nm) may potentially prevent bacterial functions that lead to infections. As a first step in this direction, various nanoparticles have been explored for improving bacteria and biofilm penetration, generating reactive oxygen species, and killing bacteria, potentially providing a novel method for fighting infections that is nondrug related. This review article will first examine in detail the mechanisms and applications of some of these nanoparticles, then follow with some recent material designs utilizing nanotechnology that are centered on fighting medical device infections.Keywords: nanomaterials, medical device infection, antibacterial, antibiotic resistance, nanoparticle, biofilms&nbsp;
format	article
author	Taylor E Webster TJ
author_facet	Taylor E Webster TJ
author_sort	Taylor E
title	Reducing infections through nanotechnology and nanoparticles
title_short	Reducing infections through nanotechnology and nanoparticles
title_full	Reducing infections through nanotechnology and nanoparticles
title_fullStr	Reducing infections through nanotechnology and nanoparticles
title_full_unstemmed	Reducing infections through nanotechnology and nanoparticles
title_sort	reducing infections through nanotechnology and nanoparticles
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/2bac7444e84c4f7b98eaa9df1381d529
work_keys_str_mv	AT taylore reducinginfectionsthroughnanotechnologyandnanoparticles AT webstertj reducinginfectionsthroughnanotechnologyandnanoparticles
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Reducing infections through nanotechnology and nanoparticles

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