Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency

Stem cell plasticity is crucial for early embryo development and the differentiation of stem cells. Here, the authors show that the extracellular protein Cripto sustains mouse ESC self-renewal and maintains mouse EpiSC as well as human ESC pluripotency and controls the metabolic reprogramming in ESC...

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Autores principales: Alessandro Fiorenzano, Emilia Pascale, Cristina D'Aniello, Dario Acampora, Cecilia Bassalert, Francesco Russo, Gennaro Andolfi, Mauro Biffoni, Federica Francescangeli, Ann Zeuner, Claudia Angelini, Claire Chazaud, Eduardo J. Patriarca, Annalisa Fico, Gabriella Minchiotti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2bb01357f66344a6adf138525180fdf0
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spelling oai:doaj.org-article:2bb01357f66344a6adf138525180fdf02021-12-02T17:32:37ZCripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency10.1038/ncomms125892041-1723https://doaj.org/article/2bb01357f66344a6adf138525180fdf02016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12589https://doaj.org/toc/2041-1723Stem cell plasticity is crucial for early embryo development and the differentiation of stem cells. Here, the authors show that the extracellular protein Cripto sustains mouse ESC self-renewal and maintains mouse EpiSC as well as human ESC pluripotency and controls the metabolic reprogramming in ESCs to EpiSC transition.Alessandro FiorenzanoEmilia PascaleCristina D'AnielloDario AcamporaCecilia BassalertFrancesco RussoGennaro AndolfiMauro BiffoniFederica FrancescangeliAnn ZeunerClaudia AngeliniClaire ChazaudEduardo J. PatriarcaAnnalisa FicoGabriella MinchiottiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alessandro Fiorenzano
Emilia Pascale
Cristina D'Aniello
Dario Acampora
Cecilia Bassalert
Francesco Russo
Gennaro Andolfi
Mauro Biffoni
Federica Francescangeli
Ann Zeuner
Claudia Angelini
Claire Chazaud
Eduardo J. Patriarca
Annalisa Fico
Gabriella Minchiotti
Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
description Stem cell plasticity is crucial for early embryo development and the differentiation of stem cells. Here, the authors show that the extracellular protein Cripto sustains mouse ESC self-renewal and maintains mouse EpiSC as well as human ESC pluripotency and controls the metabolic reprogramming in ESCs to EpiSC transition.
format article
author Alessandro Fiorenzano
Emilia Pascale
Cristina D'Aniello
Dario Acampora
Cecilia Bassalert
Francesco Russo
Gennaro Andolfi
Mauro Biffoni
Federica Francescangeli
Ann Zeuner
Claudia Angelini
Claire Chazaud
Eduardo J. Patriarca
Annalisa Fico
Gabriella Minchiotti
author_facet Alessandro Fiorenzano
Emilia Pascale
Cristina D'Aniello
Dario Acampora
Cecilia Bassalert
Francesco Russo
Gennaro Andolfi
Mauro Biffoni
Federica Francescangeli
Ann Zeuner
Claudia Angelini
Claire Chazaud
Eduardo J. Patriarca
Annalisa Fico
Gabriella Minchiotti
author_sort Alessandro Fiorenzano
title Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
title_short Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
title_full Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
title_fullStr Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
title_full_unstemmed Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
title_sort cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/2bb01357f66344a6adf138525180fdf0
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