Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

Isabel Devesa1, Rosa Planells-Cases2, Gregorio Fern&aacute;ndez-Ballester1, Jos&eacute; Manuel Gonz&aacute;lez-Ros1, Antonio Ferrer-Montiel1, Asia Fern&aacute;ndez-Carvajal11Instituto de Biolog&iacute;a Molecular y Celular, Universidad Miguel Hern&aacu...

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Autores principales:	Devesa I, Planells-Cases R, Fern&aacute;ndez-Ballester GJ, Gonz&aacute;lez-Ros JM, Ferrer-Montiel AV, Fern&aacute;ndez-Carvajal AM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2bb2615075c24fab94f155ea425dd5ce
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spelling	oai:doaj.org-article:2bb2615075c24fab94f155ea425dd5ce2021-12-02T07:24:47ZRole of the transient receptor potential vanilloid 1 in inflammation and sepsis1178-7031https://doaj.org/article/2bb2615075c24fab94f155ea425dd5ce2011-05-01T00:00:00Zhttp://www.dovepress.com/role-of-the-transient-receptor-potential-vanilloid-1-in-inflammation-a-a7522https://doaj.org/toc/1178-7031Isabel Devesa1, Rosa Planells-Cases2, Gregorio Fern&aacute;ndez-Ballester1, Jos&eacute; Manuel Gonz&aacute;lez-Ros1, Antonio Ferrer-Montiel1, Asia Fern&aacute;ndez-Carvajal11Instituto de Biolog&iacute;a Molecular y Celular, Universidad Miguel Hern&aacute;ndez, Alicante; 2Centro de Investigaci&oacute;n Pr&iacute;ncipe Felipe, Valencia, SpainAbstract: The transient receptor potential vanilloid 1 (TRPV1) is a thermoreceptor that responds to noxious temperatures, as well as to chemical agonists, such as vanilloids and protons. In addition, its channel activity is notably potentiated by proinflammatory mediators released upon tissue damage. The TRPV1 contribution to sensory neuron sensitization by proalgesic agents has signaled this receptor as a prime target for analgesic and anti-inflammatory drug intervention. However, TRPV1 antagonists have notably failed in clinical and preclinical studies because of their unwanted side effects. Recent reports have unveiled previously unrecognized anti-inflammatory and protective functions of TRPV1 in several diseases. For instance, this channel has been suggested to play an anti-inflammatory role in sepsis. Therefore, the use of potent TRPV1 antagonists as a general strategy to treat inflammation must be cautiously considered, given the deleterious effects that may arise from inhibiting the population of channels that have a protective function. The use of TRPV1 antagonists may be limited to treating those pathologies where enhanced receptor activity contributes to the inflamed state. Alternatively, therapeutic paradigms, such as reduction of inflammatory-mediated increase of receptor expression in the cell surface, may be a better strategy to prevent abrogation of the TRPV1 subpopulation involved in anti-inflammatory and protective processes.Keywords: transient receptor potential, nociceptor, capsaicin, pain, ion channel, analgesiaDevesa IPlanells-Cases RFern&aacute;ndez-Ballester GJGonz&aacute;lez-Ros JMFerrer-Montiel AVFern&aacute;ndez-Carvajal AMDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2011, Iss default, Pp 67-81 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Devesa I Planells-Cases R Fern&aacute;ndez-Ballester GJ Gonz&aacute;lez-Ros JM Ferrer-Montiel AV Fern&aacute;ndez-Carvajal AM Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
description	Isabel Devesa1, Rosa Planells-Cases2, Gregorio Fern&aacute;ndez-Ballester1, Jos&eacute; Manuel Gonz&aacute;lez-Ros1, Antonio Ferrer-Montiel1, Asia Fern&aacute;ndez-Carvajal11Instituto de Biolog&iacute;a Molecular y Celular, Universidad Miguel Hern&aacute;ndez, Alicante; 2Centro de Investigaci&oacute;n Pr&iacute;ncipe Felipe, Valencia, SpainAbstract: The transient receptor potential vanilloid 1 (TRPV1) is a thermoreceptor that responds to noxious temperatures, as well as to chemical agonists, such as vanilloids and protons. In addition, its channel activity is notably potentiated by proinflammatory mediators released upon tissue damage. The TRPV1 contribution to sensory neuron sensitization by proalgesic agents has signaled this receptor as a prime target for analgesic and anti-inflammatory drug intervention. However, TRPV1 antagonists have notably failed in clinical and preclinical studies because of their unwanted side effects. Recent reports have unveiled previously unrecognized anti-inflammatory and protective functions of TRPV1 in several diseases. For instance, this channel has been suggested to play an anti-inflammatory role in sepsis. Therefore, the use of potent TRPV1 antagonists as a general strategy to treat inflammation must be cautiously considered, given the deleterious effects that may arise from inhibiting the population of channels that have a protective function. The use of TRPV1 antagonists may be limited to treating those pathologies where enhanced receptor activity contributes to the inflamed state. Alternatively, therapeutic paradigms, such as reduction of inflammatory-mediated increase of receptor expression in the cell surface, may be a better strategy to prevent abrogation of the TRPV1 subpopulation involved in anti-inflammatory and protective processes.Keywords: transient receptor potential, nociceptor, capsaicin, pain, ion channel, analgesia
format	article
author	Devesa I Planells-Cases R Fern&aacute;ndez-Ballester GJ Gonz&aacute;lez-Ros JM Ferrer-Montiel AV Fern&aacute;ndez-Carvajal AM
author_facet	Devesa I Planells-Cases R Fern&aacute;ndez-Ballester GJ Gonz&aacute;lez-Ros JM Ferrer-Montiel AV Fern&aacute;ndez-Carvajal AM
author_sort	Devesa I
title	Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
title_short	Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
title_full	Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
title_fullStr	Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
title_full_unstemmed	Role of the transient receptor potential vanilloid 1 in inflammation and sepsis
title_sort	role of the transient receptor potential vanilloid 1 in inflammation and sepsis
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/2bb2615075c24fab94f155ea425dd5ce
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Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

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