Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake

Studying the contribution of pairs of genes to complex traits has been challenging. Here, the authors combine exome and genotype data with RNAi to screen for genetic interactions between 30 genes identified in lipid GWAS to hint at pairs whose joint modulation may improve lipid-lowering therapies.

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Autores principales:	Magdalena Zimoń, Yunfeng Huang, Anthi Trasta, Aliaksandr Halavatyi, Jimmy Z. Liu, Chia-Yen Chen, Peter Blattmann, Bernd Klaus, Christopher D. Whelan, David Sexton, Sally John, Wolfgang Huber, Ellen A. Tsai, Rainer Pepperkok, Heiko Runz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bb3a6e883434f35aa8c3f3734f6d85f
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spelling	oai:doaj.org-article:2bb3a6e883434f35aa8c3f3734f6d85f2021-11-08T11:06:10ZPairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake10.1038/s41467-021-26761-32041-1723https://doaj.org/article/2bb3a6e883434f35aa8c3f3734f6d85f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26761-3https://doaj.org/toc/2041-1723Studying the contribution of pairs of genes to complex traits has been challenging. Here, the authors combine exome and genotype data with RNAi to screen for genetic interactions between 30 genes identified in lipid GWAS to hint at pairs whose joint modulation may improve lipid-lowering therapies.Magdalena ZimońYunfeng HuangAnthi TrastaAliaksandr HalavatyiJimmy Z. LiuChia-Yen ChenPeter BlattmannBernd KlausChristopher D. WhelanDavid SextonSally JohnWolfgang HuberEllen A. TsaiRainer PepperkokHeiko RunzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Magdalena Zimoń Yunfeng Huang Anthi Trasta Aliaksandr Halavatyi Jimmy Z. Liu Chia-Yen Chen Peter Blattmann Bernd Klaus Christopher D. Whelan David Sexton Sally John Wolfgang Huber Ellen A. Tsai Rainer Pepperkok Heiko Runz Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake
description	Studying the contribution of pairs of genes to complex traits has been challenging. Here, the authors combine exome and genotype data with RNAi to screen for genetic interactions between 30 genes identified in lipid GWAS to hint at pairs whose joint modulation may improve lipid-lowering therapies.
format	article
author	Magdalena Zimoń Yunfeng Huang Anthi Trasta Aliaksandr Halavatyi Jimmy Z. Liu Chia-Yen Chen Peter Blattmann Bernd Klaus Christopher D. Whelan David Sexton Sally John Wolfgang Huber Ellen A. Tsai Rainer Pepperkok Heiko Runz
author_facet	Magdalena Zimoń Yunfeng Huang Anthi Trasta Aliaksandr Halavatyi Jimmy Z. Liu Chia-Yen Chen Peter Blattmann Bernd Klaus Christopher D. Whelan David Sexton Sally John Wolfgang Huber Ellen A. Tsai Rainer Pepperkok Heiko Runz
author_sort	Magdalena Zimoń
title	Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake
title_short	Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake
title_full	Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake
title_fullStr	Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake
title_full_unstemmed	Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake
title_sort	pairwise effects between lipid gwas genes modulate lipid plasma levels and cellular uptake
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2bb3a6e883434f35aa8c3f3734f6d85f
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Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake

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