Systems-wide effects of short-term feed deprivation in obese mice

Abstract While prolonged fasting induces significant metabolic changes in humans and mice, less is known about systems-wide metabolic changes in response to short-term feed deprivation, which is used in experimental animal studies prior to metabolic challenge tests. We here performed a systems biolo...

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Autores principales:	Daniel Andersen, Henrik Munch Roager, Li Zhang, Janne Marie Moll, Henrik Lauritz Frandsen, Niels Banhos Danneskiold-Samsøe, Axel Kornerup Hansen, Karsten Kristiansen, Tine Rask Licht, Susanne Brix
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2bb7adbd73ae47139d04f4ea13106c4c
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spelling	oai:doaj.org-article:2bb7adbd73ae47139d04f4ea13106c4c2021-12-02T13:19:29ZSystems-wide effects of short-term feed deprivation in obese mice10.1038/s41598-021-85020-z2045-2322https://doaj.org/article/2bb7adbd73ae47139d04f4ea13106c4c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85020-zhttps://doaj.org/toc/2045-2322Abstract While prolonged fasting induces significant metabolic changes in humans and mice, less is known about systems-wide metabolic changes in response to short-term feed deprivation, which is used in experimental animal studies prior to metabolic challenge tests. We here performed a systems biology-based investigation of connections between gut bacterial composition and function, inflammatory and metabolic parameters in the intestine, liver, visceral adipose tissue, blood and urine in high-fat fed, obese mice that were feed deprived up to 12 h. The systems-wide analysis revealed that feed deprivation linked to enhanced intestinal butyric acid production and expression of the gene encoding the pro-thermogenic uncoupling protein UCP1 in visceral adipose tissue of obese mice. Ucp1 expression was also positively associated with Il33 expression in ileum, colon and adipose tissue as well as with the abundance of colonic Porphyromonadaceae, the latter also correlating to cecal butyric acid levels. Collectively, the data highlighted presence of a multi-tiered system of inter-tissue communication involving intestinal, immune and metabolic functions which is affected by feed deprivation in obese mice, thus pointing to careful use of short-feed deprivation in metabolic studies using obese mice.Daniel AndersenHenrik Munch RoagerLi ZhangJanne Marie MollHenrik Lauritz FrandsenNiels Banhos Danneskiold-SamsøeAxel Kornerup HansenKarsten KristiansenTine Rask LichtSusanne BrixNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Andersen Henrik Munch Roager Li Zhang Janne Marie Moll Henrik Lauritz Frandsen Niels Banhos Danneskiold-Samsøe Axel Kornerup Hansen Karsten Kristiansen Tine Rask Licht Susanne Brix Systems-wide effects of short-term feed deprivation in obese mice
description	Abstract While prolonged fasting induces significant metabolic changes in humans and mice, less is known about systems-wide metabolic changes in response to short-term feed deprivation, which is used in experimental animal studies prior to metabolic challenge tests. We here performed a systems biology-based investigation of connections between gut bacterial composition and function, inflammatory and metabolic parameters in the intestine, liver, visceral adipose tissue, blood and urine in high-fat fed, obese mice that were feed deprived up to 12 h. The systems-wide analysis revealed that feed deprivation linked to enhanced intestinal butyric acid production and expression of the gene encoding the pro-thermogenic uncoupling protein UCP1 in visceral adipose tissue of obese mice. Ucp1 expression was also positively associated with Il33 expression in ileum, colon and adipose tissue as well as with the abundance of colonic Porphyromonadaceae, the latter also correlating to cecal butyric acid levels. Collectively, the data highlighted presence of a multi-tiered system of inter-tissue communication involving intestinal, immune and metabolic functions which is affected by feed deprivation in obese mice, thus pointing to careful use of short-feed deprivation in metabolic studies using obese mice.
format	article
author	Daniel Andersen Henrik Munch Roager Li Zhang Janne Marie Moll Henrik Lauritz Frandsen Niels Banhos Danneskiold-Samsøe Axel Kornerup Hansen Karsten Kristiansen Tine Rask Licht Susanne Brix
author_facet	Daniel Andersen Henrik Munch Roager Li Zhang Janne Marie Moll Henrik Lauritz Frandsen Niels Banhos Danneskiold-Samsøe Axel Kornerup Hansen Karsten Kristiansen Tine Rask Licht Susanne Brix
author_sort	Daniel Andersen
title	Systems-wide effects of short-term feed deprivation in obese mice
title_short	Systems-wide effects of short-term feed deprivation in obese mice
title_full	Systems-wide effects of short-term feed deprivation in obese mice
title_fullStr	Systems-wide effects of short-term feed deprivation in obese mice
title_full_unstemmed	Systems-wide effects of short-term feed deprivation in obese mice
title_sort	systems-wide effects of short-term feed deprivation in obese mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2bb7adbd73ae47139d04f4ea13106c4c
work_keys_str_mv	AT danielandersen systemswideeffectsofshorttermfeeddeprivationinobesemice AT henrikmunchroager systemswideeffectsofshorttermfeeddeprivationinobesemice AT lizhang systemswideeffectsofshorttermfeeddeprivationinobesemice AT jannemariemoll systemswideeffectsofshorttermfeeddeprivationinobesemice AT henriklauritzfrandsen systemswideeffectsofshorttermfeeddeprivationinobesemice AT nielsbanhosdanneskioldsamsøe systemswideeffectsofshorttermfeeddeprivationinobesemice AT axelkorneruphansen systemswideeffectsofshorttermfeeddeprivationinobesemice AT karstenkristiansen systemswideeffectsofshorttermfeeddeprivationinobesemice AT tinerasklicht systemswideeffectsofshorttermfeeddeprivationinobesemice AT susannebrix systemswideeffectsofshorttermfeeddeprivationinobesemice
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Systems-wide effects of short-term feed deprivation in obese mice

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