Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

Polycystic kidney disease (PKD) is characterized by the formation of large fluid-filled cysts. Here Flowers and colleagues show that loss of Lkb1, downregulated in PKD, renders kidney cells dependent on glutamine for growth, and suggest that inhibition of glutamine metabolism may prevent cyst develo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ebony M. Flowers, Jessica Sudderth, Lauren Zacharias, Glenda Mernaugh, Roy Zent, Ralph J. DeBerardinis, Thomas J. Carroll
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bb7dc69954d4d07aea6f8ecaf917710
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2bb7dc69954d4d07aea6f8ecaf917710
record_format	dspace
spelling	oai:doaj.org-article:2bb7dc69954d4d07aea6f8ecaf9177102021-12-02T16:56:39ZLkb1 deficiency confers glutamine dependency in polycystic kidney disease10.1038/s41467-018-03036-y2041-1723https://doaj.org/article/2bb7dc69954d4d07aea6f8ecaf9177102018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03036-yhttps://doaj.org/toc/2041-1723Polycystic kidney disease (PKD) is characterized by the formation of large fluid-filled cysts. Here Flowers and colleagues show that loss of Lkb1, downregulated in PKD, renders kidney cells dependent on glutamine for growth, and suggest that inhibition of glutamine metabolism may prevent cyst development in PKD.Ebony M. FlowersJessica SudderthLauren ZachariasGlenda MernaughRoy ZentRalph J. DeBerardinisThomas J. CarrollNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ebony M. Flowers Jessica Sudderth Lauren Zacharias Glenda Mernaugh Roy Zent Ralph J. DeBerardinis Thomas J. Carroll Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
description	Polycystic kidney disease (PKD) is characterized by the formation of large fluid-filled cysts. Here Flowers and colleagues show that loss of Lkb1, downregulated in PKD, renders kidney cells dependent on glutamine for growth, and suggest that inhibition of glutamine metabolism may prevent cyst development in PKD.
format	article
author	Ebony M. Flowers Jessica Sudderth Lauren Zacharias Glenda Mernaugh Roy Zent Ralph J. DeBerardinis Thomas J. Carroll
author_facet	Ebony M. Flowers Jessica Sudderth Lauren Zacharias Glenda Mernaugh Roy Zent Ralph J. DeBerardinis Thomas J. Carroll
author_sort	Ebony M. Flowers
title	Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
title_short	Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
title_full	Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
title_fullStr	Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
title_full_unstemmed	Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
title_sort	lkb1 deficiency confers glutamine dependency in polycystic kidney disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2bb7dc69954d4d07aea6f8ecaf917710
work_keys_str_mv	AT ebonymflowers lkb1deficiencyconfersglutaminedependencyinpolycystickidneydisease AT jessicasudderth lkb1deficiencyconfersglutaminedependencyinpolycystickidneydisease AT laurenzacharias lkb1deficiencyconfersglutaminedependencyinpolycystickidneydisease AT glendamernaugh lkb1deficiencyconfersglutaminedependencyinpolycystickidneydisease AT royzent lkb1deficiencyconfersglutaminedependencyinpolycystickidneydisease AT ralphjdeberardinis lkb1deficiencyconfersglutaminedependencyinpolycystickidneydisease AT thomasjcarroll lkb1deficiencyconfersglutaminedependencyinpolycystickidneydisease
_version_	1718382731074732032

Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

Ejemplares similares