Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.

The digenetic trematode Schistosoma mansoni is a human parasite that uses the mollusc Biomphalaria glabrata as intermediate host. Specific S. mansoni strains can infect efficiently only certain B. glabrata strains (compatible strain) while others are incompatible. Strain-specific differences in tran...

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Autores principales:	Cecile Perrin, Julie M J Lepesant, Emmanuel Roger, David Duval, Sara Fneich, Virginie Thuillier, Jean-Francois Alliene, Guillaume Mitta, Christoph Grunau, Celine Cosseau
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2bb82172041c4cbcada2c6729c01184f
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spelling	oai:doaj.org-article:2bb82172041c4cbcada2c6729c01184f2021-11-18T06:07:43ZSchistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.1553-73661553-737410.1371/journal.ppat.1003571https://doaj.org/article/2bb82172041c4cbcada2c6729c01184f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24009504/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The digenetic trematode Schistosoma mansoni is a human parasite that uses the mollusc Biomphalaria glabrata as intermediate host. Specific S. mansoni strains can infect efficiently only certain B. glabrata strains (compatible strain) while others are incompatible. Strain-specific differences in transcription of a conserved family of polymorphic mucins (SmPoMucs) in S. mansoni are the principle determinants for this compatibility. In the present study, we investigated the bases of the control of SmPoMuc expression that evolved to evade B. glabrata diversified antigen recognition molecules. We compared the DNA sequences and chromatin structure of SmPoMuc promoters of two S. mansoni strains that are either compatible (C) or incompatible (IC) with a reference snail host. We reveal that although sequence differences are observed between active promoter regions of SmPoMuc genes, the sequences of the promoters are not diverse and are conserved between IC and C strains, suggesting that genetics alone cannot explain the evolution of compatibility polymorphism. In contrast, promoters carry epigenetic marks that are significantly different between the C and IC strains. Moreover, we show that modifications of the structure of the chromatin of the parasite modify transcription of SmPoMuc in the IC strain compared to the C strain and correlate with the presence of additional combinations of SmPoMuc transcripts only observed in the IC phenotype. Our results indicate that transcription polymorphism of a gene family that is responsible for an important adaptive trait of the parasite is epigenetically encoded. These strain-specific epigenetic marks are heritable, but can change while the underlying genetic information remains stable. This suggests that epigenetic changes may be important for the early steps in the adaptation of pathogens to new hosts, and might be an initial step in adaptive evolution in general.Cecile PerrinJulie M J LepesantEmmanuel RogerDavid DuvalSara FneichVirginie ThuillierJean-Francois AllieneGuillaume MittaChristoph GrunauCeline CosseauPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 8, p e1003571 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Cecile Perrin Julie M J Lepesant Emmanuel Roger David Duval Sara Fneich Virginie Thuillier Jean-Francois Alliene Guillaume Mitta Christoph Grunau Celine Cosseau Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.
description	The digenetic trematode Schistosoma mansoni is a human parasite that uses the mollusc Biomphalaria glabrata as intermediate host. Specific S. mansoni strains can infect efficiently only certain B. glabrata strains (compatible strain) while others are incompatible. Strain-specific differences in transcription of a conserved family of polymorphic mucins (SmPoMucs) in S. mansoni are the principle determinants for this compatibility. In the present study, we investigated the bases of the control of SmPoMuc expression that evolved to evade B. glabrata diversified antigen recognition molecules. We compared the DNA sequences and chromatin structure of SmPoMuc promoters of two S. mansoni strains that are either compatible (C) or incompatible (IC) with a reference snail host. We reveal that although sequence differences are observed between active promoter regions of SmPoMuc genes, the sequences of the promoters are not diverse and are conserved between IC and C strains, suggesting that genetics alone cannot explain the evolution of compatibility polymorphism. In contrast, promoters carry epigenetic marks that are significantly different between the C and IC strains. Moreover, we show that modifications of the structure of the chromatin of the parasite modify transcription of SmPoMuc in the IC strain compared to the C strain and correlate with the presence of additional combinations of SmPoMuc transcripts only observed in the IC phenotype. Our results indicate that transcription polymorphism of a gene family that is responsible for an important adaptive trait of the parasite is epigenetically encoded. These strain-specific epigenetic marks are heritable, but can change while the underlying genetic information remains stable. This suggests that epigenetic changes may be important for the early steps in the adaptation of pathogens to new hosts, and might be an initial step in adaptive evolution in general.
format	article
author	Cecile Perrin Julie M J Lepesant Emmanuel Roger David Duval Sara Fneich Virginie Thuillier Jean-Francois Alliene Guillaume Mitta Christoph Grunau Celine Cosseau
author_facet	Cecile Perrin Julie M J Lepesant Emmanuel Roger David Duval Sara Fneich Virginie Thuillier Jean-Francois Alliene Guillaume Mitta Christoph Grunau Celine Cosseau
author_sort	Cecile Perrin
title	Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.
title_short	Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.
title_full	Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.
title_fullStr	Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.
title_full_unstemmed	Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.
title_sort	schistosoma mansoni mucin gene (smpomuc) expression: epigenetic control to shape adaptation to a new host.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2bb82172041c4cbcada2c6729c01184f
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Schistosoma mansoni mucin gene (SmPoMuc) expression: epigenetic control to shape adaptation to a new host.

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