Widespread intronic polyadenylation diversifies immune cell transcriptomes

Widespread intronic polyadenylation diversifies immune cell transcriptomes

Recognition of intronic polyadenylation (IpA) signals can lead to expression of truncated proteins lacking C terminal domains. Analysis of 3ʹ -seq and RNA-seq shows that IpA is widespread in circulating immune cells, while multiple myeloma cells show loss of IpA isoforms that are normally expressed...

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Autores principales: Irtisha Singh, Shih-Han Lee, Adam S. Sperling, Mehmet K. Samur, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C. Munshi, Christine Mayr, Christina S. Leslie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2bbdcae153214b559f2c223b91762442
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spelling oai:doaj.org-article:2bbdcae153214b559f2c223b917624422021-12-02T16:56:57ZWidespread intronic polyadenylation diversifies immune cell transcriptomes10.1038/s41467-018-04112-z2041-1723https://doaj.org/article/2bbdcae153214b559f2c223b917624422018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04112-zhttps://doaj.org/toc/2041-1723Recognition of intronic polyadenylation (IpA) signals can lead to expression of truncated proteins lacking C terminal domains. Analysis of 3ʹ -seq and RNA-seq shows that IpA is widespread in circulating immune cells, while multiple myeloma cells show loss of IpA isoforms that are normally expressed in plasma cells, impacting key genes in the disease.Irtisha SinghShih-Han LeeAdam S. SperlingMehmet K. SamurYu-Tzu TaiMariateresa FulcinitiNikhil C. MunshiChristine MayrChristina S. LeslieNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Irtisha Singh
Shih-Han Lee
Adam S. Sperling
Mehmet K. Samur
Yu-Tzu Tai
Mariateresa Fulciniti
Nikhil C. Munshi
Christine Mayr
Christina S. Leslie
Widespread intronic polyadenylation diversifies immune cell transcriptomes
description Recognition of intronic polyadenylation (IpA) signals can lead to expression of truncated proteins lacking C terminal domains. Analysis of 3ʹ -seq and RNA-seq shows that IpA is widespread in circulating immune cells, while multiple myeloma cells show loss of IpA isoforms that are normally expressed in plasma cells, impacting key genes in the disease.
format article
author Irtisha Singh
Shih-Han Lee
Adam S. Sperling
Mehmet K. Samur
Yu-Tzu Tai
Mariateresa Fulciniti
Nikhil C. Munshi
Christine Mayr
Christina S. Leslie
author_facet Irtisha Singh
Shih-Han Lee
Adam S. Sperling
Mehmet K. Samur
Yu-Tzu Tai
Mariateresa Fulciniti
Nikhil C. Munshi
Christine Mayr
Christina S. Leslie
author_sort Irtisha Singh
title Widespread intronic polyadenylation diversifies immune cell transcriptomes
title_short Widespread intronic polyadenylation diversifies immune cell transcriptomes
title_full Widespread intronic polyadenylation diversifies immune cell transcriptomes
title_fullStr Widespread intronic polyadenylation diversifies immune cell transcriptomes
title_full_unstemmed Widespread intronic polyadenylation diversifies immune cell transcriptomes
title_sort widespread intronic polyadenylation diversifies immune cell transcriptomes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/2bbdcae153214b559f2c223b91762442
work_keys_str_mv AT irtishasingh widespreadintronicpolyadenylationdiversifiesimmunecelltranscriptomes
AT shihhanlee widespreadintronicpolyadenylationdiversifiesimmunecelltranscriptomes
AT adamssperling widespreadintronicpolyadenylationdiversifiesimmunecelltranscriptomes
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AT yutzutai widespreadintronicpolyadenylationdiversifiesimmunecelltranscriptomes
AT mariateresafulciniti widespreadintronicpolyadenylationdiversifiesimmunecelltranscriptomes
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AT christinasleslie widespreadintronicpolyadenylationdiversifiesimmunecelltranscriptomes
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