Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels

Balasubramanian Subramanian,1 Sundaram Maruthamuthu,2 Senthilperumal Thanka Rajan1 1Electrochemical Material Science Division, 2Corrosion and Materials Protection Division, Central Electrochemical Research Institute, Karaikudi, India Abstract: Thin film metallic glasses comprised of Zr48Cu36Al8Ag8...

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Autores principales:	Subramanian B, Maruthamuthu S, Rajan ST
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2bc02c567e894448891b2e8d6b3cc637
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spelling	oai:doaj.org-article:2bc02c567e894448891b2e8d6b3cc6372021-12-02T01:48:46ZBiocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels1178-2013https://doaj.org/article/2bc02c567e894448891b2e8d6b3cc6372015-10-01T00:00:00Zhttps://www.dovepress.com/biocompatibility-evaluation-of-sputtered-zirconium-based-thin-film-met-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Balasubramanian Subramanian,1 Sundaram Maruthamuthu,2 Senthilperumal Thanka Rajan1 1Electrochemical Material Science Division, 2Corrosion and Materials Protection Division, Central Electrochemical Research Institute, Karaikudi, India Abstract: Thin film metallic glasses comprised of Zr48Cu36Al8Ag8 (at.%) of approximately 1.5 µm and 3 µm in thickness were prepared using magnetron sputtering onto medical grade 316L stainless steel. Their structural and mechanical properties, in vitro corrosion, and antimicrobial activity were analyzed. The amorphous thin film metallic glasses consisted of a single glassy phase, with an absence of any detectable peaks corresponding to crystalline phases. Elemental composition close to the target alloy was noted from EDAX analysis of the thin film. The surface morphology of the film showed a smooth surface on scanning electron microscopy and atomic force microscopy. In vitro electrochemical corrosion studies indicated that the zirconium-based metallic glass could withstand body fluid, showing superior resistance to corrosion and electrochemical stability. Interactions between the coated surface and bacteria were investigated by agar diffusion, solution suspension, and wet interfacial contact methods. The results indicated a clear zone of inhibition against the growth of microorganisms such as Escherichia coli and Staphylococcus aureus, confirming the antimicrobial activity of the thin film metallic glasses. Cytotoxicity studies using L929 fibroblast cells showed these coatings to be noncytotoxic in nature. Keywords: thin film metallic glasses, sputtering, biocompatibility, corrosion, antimicrobial activitySubramanian BMaruthamuthu SRajan STDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Supplement 1 Challenges in biomaterials research, Pp 17-29 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Subramanian B Maruthamuthu S Rajan ST Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels
description	Balasubramanian Subramanian,1 Sundaram Maruthamuthu,2 Senthilperumal Thanka Rajan1 1Electrochemical Material Science Division, 2Corrosion and Materials Protection Division, Central Electrochemical Research Institute, Karaikudi, India Abstract: Thin film metallic glasses comprised of Zr48Cu36Al8Ag8 (at.%) of approximately 1.5 µm and 3 µm in thickness were prepared using magnetron sputtering onto medical grade 316L stainless steel. Their structural and mechanical properties, in vitro corrosion, and antimicrobial activity were analyzed. The amorphous thin film metallic glasses consisted of a single glassy phase, with an absence of any detectable peaks corresponding to crystalline phases. Elemental composition close to the target alloy was noted from EDAX analysis of the thin film. The surface morphology of the film showed a smooth surface on scanning electron microscopy and atomic force microscopy. In vitro electrochemical corrosion studies indicated that the zirconium-based metallic glass could withstand body fluid, showing superior resistance to corrosion and electrochemical stability. Interactions between the coated surface and bacteria were investigated by agar diffusion, solution suspension, and wet interfacial contact methods. The results indicated a clear zone of inhibition against the growth of microorganisms such as Escherichia coli and Staphylococcus aureus, confirming the antimicrobial activity of the thin film metallic glasses. Cytotoxicity studies using L929 fibroblast cells showed these coatings to be noncytotoxic in nature. Keywords: thin film metallic glasses, sputtering, biocompatibility, corrosion, antimicrobial activity
format	article
author	Subramanian B Maruthamuthu S Rajan ST
author_facet	Subramanian B Maruthamuthu S Rajan ST
author_sort	Subramanian B
title	Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels
title_short	Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels
title_full	Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels
title_fullStr	Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels
title_full_unstemmed	Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels
title_sort	biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/2bc02c567e894448891b2e8d6b3cc637
work_keys_str_mv	AT subramanianb biocompatibilityevaluationofsputteredzirconiumbasedthinfilmmetallicglasscoatedsteels AT maruthamuthus biocompatibilityevaluationofsputteredzirconiumbasedthinfilmmetallicglasscoatedsteels AT rajanst biocompatibilityevaluationofsputteredzirconiumbasedthinfilmmetallicglasscoatedsteels
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Biocompatibility evaluation of sputtered zirconium-based thin film metallic glass-coated steels

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