Efficacy and Safety of the Cudrania tricuspidata Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study

Cudrania tricuspidata is a folk remedy used to treat inflammation in patients with tumors or liver damage. This study investigated the efficacy of Cudrania tricuspidata extract (CTE) for relieving the symptoms of functional dyspepsia. In an 8-week, randomized, d...

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Autores principales:	Jinyoung Shin, Tae-Hoon Oh, Joo-Yun Kim, Jae-Jung Shim, Jung-Lyoul Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Cudrania tricuspidata</i> dyspepsia clinical trials Medicine R
Acceso en línea:	https://doaj.org/article/2bc043a0b5584640bcb1f7fdced734d7
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spelling	oai:doaj.org-article:2bc043a0b5584640bcb1f7fdced734d72021-11-25T18:01:45ZEfficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study10.3390/jcm102253232077-0383https://doaj.org/article/2bc043a0b5584640bcb1f7fdced734d72021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5323https://doaj.org/toc/2077-0383<i>Cudrania tricuspidata</i> is a folk remedy used to treat inflammation in patients with tumors or liver damage. This study investigated the efficacy of <i>Cudrania tricuspidata</i> extract (CTE) for relieving the symptoms of functional dyspepsia. In an 8-week, randomized, double-blind, placebo-controlled study, 100 adults with any condition featured in the Rome IV criteria and a Gastrointestinal Symptoms Scale (GIS) score ≥4 were randomly allocated to take either a placebo (maltodextrin) or a 50 mg CTE tablet, which equally included celluloses, magnesium stearate, and silicon dioxide, twice daily, 20 January 2020, and 3 August 2020. Among the 83 participants finally analyzed, the CTE group was associated with a significant reduction in the gastrointestinal symptom rating scale (day 0: 8.0 ± 5.2, day 28: 4.7 ± 3.9, and day 56: 2.3 ± 2.4, <i>p</i> < 0.001, respectively) in comparison with the control group (day 0: 8.1 ± 4.7, day 28: 7.8 ± 5.7, and day 56: 7.5 ± 6.6, <i>p</i> > 0.05) after adjusting for smoking, drinking, eating habits, stress levels, and caffeine intake. The CTE group resulted in significant improvements of GIS, Nepean Dyspepsia Index (Korean version), and functional dyspepsia-related quality of life over time. There were no different adverse events (<i>p</i> = 0.523). These findings suggest that CTE is safe and efficacious for alleviating gastrointestinal symptoms in patients with functional dyspepsia.Jinyoung ShinTae-Hoon OhJoo-Yun KimJae-Jung ShimJung-Lyoul LeeMDPI AGarticle<i>Cudrania tricuspidata</i>dyspepsiaclinical trialsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5323, p 5323 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Cudrania tricuspidata</i> dyspepsia clinical trials Medicine R
spellingShingle	<i>Cudrania tricuspidata</i> dyspepsia clinical trials Medicine R Jinyoung Shin Tae-Hoon Oh Joo-Yun Kim Jae-Jung Shim Jung-Lyoul Lee Efficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study
description	<i>Cudrania tricuspidata</i> is a folk remedy used to treat inflammation in patients with tumors or liver damage. This study investigated the efficacy of <i>Cudrania tricuspidata</i> extract (CTE) for relieving the symptoms of functional dyspepsia. In an 8-week, randomized, double-blind, placebo-controlled study, 100 adults with any condition featured in the Rome IV criteria and a Gastrointestinal Symptoms Scale (GIS) score ≥4 were randomly allocated to take either a placebo (maltodextrin) or a 50 mg CTE tablet, which equally included celluloses, magnesium stearate, and silicon dioxide, twice daily, 20 January 2020, and 3 August 2020. Among the 83 participants finally analyzed, the CTE group was associated with a significant reduction in the gastrointestinal symptom rating scale (day 0: 8.0 ± 5.2, day 28: 4.7 ± 3.9, and day 56: 2.3 ± 2.4, <i>p</i> < 0.001, respectively) in comparison with the control group (day 0: 8.1 ± 4.7, day 28: 7.8 ± 5.7, and day 56: 7.5 ± 6.6, <i>p</i> > 0.05) after adjusting for smoking, drinking, eating habits, stress levels, and caffeine intake. The CTE group resulted in significant improvements of GIS, Nepean Dyspepsia Index (Korean version), and functional dyspepsia-related quality of life over time. There were no different adverse events (<i>p</i> = 0.523). These findings suggest that CTE is safe and efficacious for alleviating gastrointestinal symptoms in patients with functional dyspepsia.
format	article
author	Jinyoung Shin Tae-Hoon Oh Joo-Yun Kim Jae-Jung Shim Jung-Lyoul Lee
author_facet	Jinyoung Shin Tae-Hoon Oh Joo-Yun Kim Jae-Jung Shim Jung-Lyoul Lee
author_sort	Jinyoung Shin
title	Efficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study
title_short	Efficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study
title_full	Efficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study
title_fullStr	Efficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study
title_full_unstemmed	Efficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study
title_sort	efficacy and safety of the <i>cudrania tricuspidata</i> extract on functional dyspepsia: a randomized double-blind placebo-controlled multicenter study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2bc043a0b5584640bcb1f7fdced734d7
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Efficacy and Safety of the <i>Cudrania tricuspidata</i> Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study

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