Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway

Abstract Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Thro...

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Autores principales:	Huxiao Li, Jianrong Xu, Xiaotian Li, Yi Hu, Yue Liao, Wei Zhou, Zhongchen Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2bc7238f343d4d74a6bb35e97841715e
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spelling	oai:doaj.org-article:2bc7238f343d4d74a6bb35e97841715e2021-12-02T17:32:58ZAnti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway10.1038/s41598-021-85145-12045-2322https://doaj.org/article/2bc7238f343d4d74a6bb35e97841715e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85145-1https://doaj.org/toc/2045-2322Abstract Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.Huxiao LiJianrong XuXiaotian LiYi HuYue LiaoWei ZhouZhongchen SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huxiao Li Jianrong Xu Xiaotian Li Yi Hu Yue Liao Wei Zhou Zhongchen Song Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
description	Abstract Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ERα than ERβ. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-κb signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.
format	article
author	Huxiao Li Jianrong Xu Xiaotian Li Yi Hu Yue Liao Wei Zhou Zhongchen Song
author_facet	Huxiao Li Jianrong Xu Xiaotian Li Yi Hu Yue Liao Wei Zhou Zhongchen Song
author_sort	Huxiao Li
title	Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
title_short	Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
title_full	Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
title_fullStr	Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
title_full_unstemmed	Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
title_sort	anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2bc7238f343d4d74a6bb35e97841715e
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Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway

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