Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

Guaianolides are pharmaceutically interesting molecules. Here, the authors isolate the enzyme kauniolide synthase from feverfew, show that it converts constunolide into a guaianolide via an unusual mechanism of action, and reconstruct the full kauniolide biosynthesis pathway in host organisms.

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Autores principales:	Qing Liu, Arman Beyraghdar Kashkooli, David Manzano, Irini Pateraki, Lea Richard, Pim Kolkman, Maria Fátima Lucas, Victor Guallar, Ric C.H. de Vos, Maurice C. R. Franssen, Alexander van der Krol, Harro Bouwmeester
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bca8e4a2e3b473f86c74e293fd3548d
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spelling	oai:doaj.org-article:2bca8e4a2e3b473f86c74e293fd3548d2021-12-02T16:49:51ZKauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity10.1038/s41467-018-06565-82041-1723https://doaj.org/article/2bca8e4a2e3b473f86c74e293fd3548d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06565-8https://doaj.org/toc/2041-1723Guaianolides are pharmaceutically interesting molecules. Here, the authors isolate the enzyme kauniolide synthase from feverfew, show that it converts constunolide into a guaianolide via an unusual mechanism of action, and reconstruct the full kauniolide biosynthesis pathway in host organisms.Qing LiuArman Beyraghdar KashkooliDavid ManzanoIrini PaterakiLea RichardPim KolkmanMaria Fátima LucasVictor GuallarRic C.H. de VosMaurice C. R. FranssenAlexander van der KrolHarro BouwmeesterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing Liu Arman Beyraghdar Kashkooli David Manzano Irini Pateraki Lea Richard Pim Kolkman Maria Fátima Lucas Victor Guallar Ric C.H. de Vos Maurice C. R. Franssen Alexander van der Krol Harro Bouwmeester Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity
description	Guaianolides are pharmaceutically interesting molecules. Here, the authors isolate the enzyme kauniolide synthase from feverfew, show that it converts constunolide into a guaianolide via an unusual mechanism of action, and reconstruct the full kauniolide biosynthesis pathway in host organisms.
format	article
author	Qing Liu Arman Beyraghdar Kashkooli David Manzano Irini Pateraki Lea Richard Pim Kolkman Maria Fátima Lucas Victor Guallar Ric C.H. de Vos Maurice C. R. Franssen Alexander van der Krol Harro Bouwmeester
author_facet	Qing Liu Arman Beyraghdar Kashkooli David Manzano Irini Pateraki Lea Richard Pim Kolkman Maria Fátima Lucas Victor Guallar Ric C.H. de Vos Maurice C. R. Franssen Alexander van der Krol Harro Bouwmeester
author_sort	Qing Liu
title	Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity
title_short	Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity
title_full	Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity
title_fullStr	Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity
title_full_unstemmed	Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity
title_sort	kauniolide synthase is a p450 with unusual hydroxylation and cyclization-elimination activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2bca8e4a2e3b473f86c74e293fd3548d
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Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

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