A novel method of screening combinations of angiostatics identifies bevacizumab and temsirolimus as synergistic inhibitors of glioma-induced angiogenesis.

A novel method of screening combinations of angiostatics identifies bevacizumab and temsirolimus as synergistic inhibitors of glioma-induced angiogenesis.

Tumor angiogenesis is critical for the growth and progression of cancer. As such, angiostasis is a treatment modality for cancer with potential utility for multiple types of cancer and fewer side effects. However, clinical success of angiostatic monotherapies has been moderate, at best, causing angi...

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Main Authors: Michael I Dorrell, Heidi R Kast-Woelbern, Ryan T Botts, Stephen A Bravo, Jacob R Tremblay, Sarah Giles, Jessica F Wada, MaryAnn Alexander, Eric Garcia, Gabriel Villegas, Caylor B Booth, Kaitlyn J Purington, Haylie M Everett, Erik N Siles, Michael Wheelock, Jordan A Silva, Bridget M Fortin, Connor A Lowey, Allison L Hale, Troy L Kurz, Jack C Rusing, Dawn M Goral, Paul Thompson, Alec M Johnson, Daniel J Elson, Roujih Tadros, Charisa E Gillette, Carley Coopwood, Amy L Rausch, Jeffrey M Snowbarger
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/2bcc474f3f2743d2ae3bcf6edb8e2f29
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