Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures

It is currently challenging to identify protein structures at low concentrations. Here the authors report optical tweezers-coupled Raman spectroscopy to generate tunable and reproducible SERS enhancements with single-molecule level sensitivity and use the method to detect protein structural features...

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Autores principales:	Xin Dai, Wenhao Fu, Huanyu Chi, Vince St. Dollente Mesias, Hongni Zhu, Cheuk Wai Leung, Wei Liu, Jinqing Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bcd2676881a44d2bcf28f55c024666a
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spelling	oai:doaj.org-article:2bcd2676881a44d2bcf28f55c024666a2021-12-02T13:15:00ZOptical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures10.1038/s41467-021-21543-32041-1723https://doaj.org/article/2bcd2676881a44d2bcf28f55c024666a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21543-3https://doaj.org/toc/2041-1723It is currently challenging to identify protein structures at low concentrations. Here the authors report optical tweezers-coupled Raman spectroscopy to generate tunable and reproducible SERS enhancements with single-molecule level sensitivity and use the method to detect protein structural features.Xin DaiWenhao FuHuanyu ChiVince St. Dollente MesiasHongni ZhuCheuk Wai LeungWei LiuJinqing HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xin Dai Wenhao Fu Huanyu Chi Vince St. Dollente Mesias Hongni Zhu Cheuk Wai Leung Wei Liu Jinqing Huang Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
description	It is currently challenging to identify protein structures at low concentrations. Here the authors report optical tweezers-coupled Raman spectroscopy to generate tunable and reproducible SERS enhancements with single-molecule level sensitivity and use the method to detect protein structural features.
format	article
author	Xin Dai Wenhao Fu Huanyu Chi Vince St. Dollente Mesias Hongni Zhu Cheuk Wai Leung Wei Liu Jinqing Huang
author_facet	Xin Dai Wenhao Fu Huanyu Chi Vince St. Dollente Mesias Hongni Zhu Cheuk Wai Leung Wei Liu Jinqing Huang
author_sort	Xin Dai
title	Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
title_short	Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
title_full	Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
title_fullStr	Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
title_full_unstemmed	Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
title_sort	optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced raman spectroscopy characterization of native protein structures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2bcd2676881a44d2bcf28f55c024666a
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Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures

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