Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures

Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures

It is currently challenging to identify protein structures at low concentrations. Here the authors report optical tweezers-coupled Raman spectroscopy to generate tunable and reproducible SERS enhancements with single-molecule level sensitivity and use the method to detect protein structural features...

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Autores principales: Xin Dai, Wenhao Fu, Huanyu Chi, Vince St. Dollente Mesias, Hongni Zhu, Cheuk Wai Leung, Wei Liu, Jinqing Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/2bcd2676881a44d2bcf28f55c024666a
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