Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy

Left atrial (LA) geometry and phasic functions are frequently impaired in non-ischaemic dilated cardiomyopathy (NIDCM). Cardiac magnetic resonance (CMR) can accurately measure LA function and geometry parameters. We sought to investigate their prognostic role in patients with NIDCM. We prospectively...

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Autores principales:	Bianca Olivia Cojan-Minzat, Alexandru Zlibut, Ioana Danuta Muresan, Rares-Ilie Orzan, Carmen Cionca, Dalma Horvat, Liliana David, Alexandru Ciprian Visan, Mira Florea, Lucia Agoston-Coldea
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	non-ischaemic dilated cardiomyopathy cardiac magnetic resonance imaging left atrial phasic function left atrial volumes left atrial sphericity index left atrial strain Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2bd038e8576a466fb71d4db3d8b40f20
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spelling	oai:doaj.org-article:2bd038e8576a466fb71d4db3d8b40f202021-11-25T16:50:15ZLeft Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy10.3390/biomedicines91116532227-9059https://doaj.org/article/2bd038e8576a466fb71d4db3d8b40f202021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1653https://doaj.org/toc/2227-9059Left atrial (LA) geometry and phasic functions are frequently impaired in non-ischaemic dilated cardiomyopathy (NIDCM). Cardiac magnetic resonance (CMR) can accurately measure LA function and geometry parameters. We sought to investigate their prognostic role in patients with NIDCM. We prospectively examined 212 patients with NIDCM (49 ± 14.2-year-old; 73.5% males) and 106 healthy controls. LA volumes, phasic functions, geometry, and fibrosis were determined using CMR. A composite outcome (cardiac death, ventricular tachyarrhythmias, heart failure hospitalization) was ascertained over a median of 26 months. LA phasic functions, sphericity index (LASI) and late gadolinium enhancement (LA-LGE) were considerably impaired in the diseased group (<i>p</i> < 0.001) and significantly correlated with impaired LV function parameters (<i>p</i> < 0.0001). After multivariate analysis, LA volumes, LASI, LA total strain (LA-ε<sub>t</sub>) and LA-LGE were associated with increased risk of composite outcome (<i>p</i> < 0.001). Kaplan–Meier analysis showed significantly higher risk of composite endpoint for LA volumes (all <i>p</i> < 0.01), LASI > 0.725 (<i>p</i> < 0.003), and LA-ε<sub>t</sub> < 30% (<i>p</i> < 0.0001). Stepwise Cox proportional-hazards models demonstrated a considerable incremental predictive value which resulted by adding LASI to LA-ε<sub>t</sub> (Chi-square = 10.2, <i>p</i> < 0.001), and afterwards LA-LGE (Chi-Square = 15.8; <i>p</i> < 0.0001). NIDCM patients with defective LA volumes, LASI, LA-LGE and LA-ε<sub>t</sub> had a higher risk for an outcome. LA-ε<sub>t</sub>, LASI and LA-LGE provided independent incremental predictive value for outcome.Bianca Olivia Cojan-MinzatAlexandru ZlibutIoana Danuta MuresanRares-Ilie OrzanCarmen CioncaDalma HorvatLiliana DavidAlexandru Ciprian VisanMira FloreaLucia Agoston-ColdeaMDPI AGarticlenon-ischaemic dilated cardiomyopathycardiac magnetic resonance imagingleft atrial phasic functionleft atrial volumesleft atrial sphericity indexleft atrial strainBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1653, p 1653 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-ischaemic dilated cardiomyopathy cardiac magnetic resonance imaging left atrial phasic function left atrial volumes left atrial sphericity index left atrial strain Biology (General) QH301-705.5
spellingShingle	non-ischaemic dilated cardiomyopathy cardiac magnetic resonance imaging left atrial phasic function left atrial volumes left atrial sphericity index left atrial strain Biology (General) QH301-705.5 Bianca Olivia Cojan-Minzat Alexandru Zlibut Ioana Danuta Muresan Rares-Ilie Orzan Carmen Cionca Dalma Horvat Liliana David Alexandru Ciprian Visan Mira Florea Lucia Agoston-Coldea Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy
description	Left atrial (LA) geometry and phasic functions are frequently impaired in non-ischaemic dilated cardiomyopathy (NIDCM). Cardiac magnetic resonance (CMR) can accurately measure LA function and geometry parameters. We sought to investigate their prognostic role in patients with NIDCM. We prospectively examined 212 patients with NIDCM (49 ± 14.2-year-old; 73.5% males) and 106 healthy controls. LA volumes, phasic functions, geometry, and fibrosis were determined using CMR. A composite outcome (cardiac death, ventricular tachyarrhythmias, heart failure hospitalization) was ascertained over a median of 26 months. LA phasic functions, sphericity index (LASI) and late gadolinium enhancement (LA-LGE) were considerably impaired in the diseased group (<i>p</i> < 0.001) and significantly correlated with impaired LV function parameters (<i>p</i> < 0.0001). After multivariate analysis, LA volumes, LASI, LA total strain (LA-ε<sub>t</sub>) and LA-LGE were associated with increased risk of composite outcome (<i>p</i> < 0.001). Kaplan–Meier analysis showed significantly higher risk of composite endpoint for LA volumes (all <i>p</i> < 0.01), LASI > 0.725 (<i>p</i> < 0.003), and LA-ε<sub>t</sub> < 30% (<i>p</i> < 0.0001). Stepwise Cox proportional-hazards models demonstrated a considerable incremental predictive value which resulted by adding LASI to LA-ε<sub>t</sub> (Chi-square = 10.2, <i>p</i> < 0.001), and afterwards LA-LGE (Chi-Square = 15.8; <i>p</i> < 0.0001). NIDCM patients with defective LA volumes, LASI, LA-LGE and LA-ε<sub>t</sub> had a higher risk for an outcome. LA-ε<sub>t</sub>, LASI and LA-LGE provided independent incremental predictive value for outcome.
format	article
author	Bianca Olivia Cojan-Minzat Alexandru Zlibut Ioana Danuta Muresan Rares-Ilie Orzan Carmen Cionca Dalma Horvat Liliana David Alexandru Ciprian Visan Mira Florea Lucia Agoston-Coldea
author_facet	Bianca Olivia Cojan-Minzat Alexandru Zlibut Ioana Danuta Muresan Rares-Ilie Orzan Carmen Cionca Dalma Horvat Liliana David Alexandru Ciprian Visan Mira Florea Lucia Agoston-Coldea
author_sort	Bianca Olivia Cojan-Minzat
title	Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy
title_short	Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy
title_full	Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy
title_fullStr	Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy
title_full_unstemmed	Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy
title_sort	left atrial geometry and phasic function determined by cardiac magnetic resonance are independent predictors for outcome in non-ischaemic dilated cardiomyopathy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2bd038e8576a466fb71d4db3d8b40f20
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Left Atrial Geometry and Phasic Function Determined by Cardiac Magnetic Resonance Are Independent Predictors for Outcome in Non-Ischaemic Dilated Cardiomyopathy

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