The role of the gut microbiota in the development of type 1 diabetes mellitus

At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gu...

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Autores principales:	L. I. Ibragimova, E. A. Kolpakova, A. V. Dzagakhova, L. V. Egshatyan, E. V. Pokrovskaya, O. S. Derevyanko, T. V. Nikonova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	microbiota type 1 diabetes mellitus gene sequencing Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/2bd2887710424625b52597886d6e70fe
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spelling	oai:doaj.org-article:2bd2887710424625b52597886d6e70fe2021-11-14T09:00:23ZThe role of the gut microbiota in the development of type 1 diabetes mellitus2072-03512072-037810.14341/DM10326https://doaj.org/article/2bd2887710424625b52597886d6e70fe2021-02-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/10326https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gut microbiota (GM) and various diseases is being actively studied, a search for specific metabolites and genes of microorganisms that may be associated with the development, in particular, of immune-mediated diseases is underway. In recent years, a lot of new data have been published on the possible contribution of gut flora dysbiosis to the development of Type 1 Diabetes Mellitus (T1DM), while the first assumptions were put forward as far back as 1970s. The search for pathogenetic mechanisms of GM influence on the development and progression of T1DM is becoming an increasingly relevant objective, since in recent years the incidence of T1DM is rapidly increasing, which is a serious health problem throughout the world.This review discusses the current ideas about the role of GM in the immunopathogenesis of T1DM, new data on the near-term prospects in the study of the human macrogenome, current ideas about the role of GM in the immunopathogenesis of T1DM, and the possibility of applying this knowledge by the practitioner.L. I. IbragimovaE. A. KolpakovaA. V. DzagakhovaL. V. EgshatyanE. V. PokrovskayaO. S. DerevyankoT. V. NikonovaEndocrinology Research Centrearticlemicrobiotatype 1 diabetes mellitusgene sequencingNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 24, Iss 1, Pp 62-69 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	microbiota type 1 diabetes mellitus gene sequencing Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	microbiota type 1 diabetes mellitus gene sequencing Nutritional diseases. Deficiency diseases RC620-627 L. I. Ibragimova E. A. Kolpakova A. V. Dzagakhova L. V. Egshatyan E. V. Pokrovskaya O. S. Derevyanko T. V. Nikonova The role of the gut microbiota in the development of type 1 diabetes mellitus
description	At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gut microbiota (GM) and various diseases is being actively studied, a search for specific metabolites and genes of microorganisms that may be associated with the development, in particular, of immune-mediated diseases is underway. In recent years, a lot of new data have been published on the possible contribution of gut flora dysbiosis to the development of Type 1 Diabetes Mellitus (T1DM), while the first assumptions were put forward as far back as 1970s. The search for pathogenetic mechanisms of GM influence on the development and progression of T1DM is becoming an increasingly relevant objective, since in recent years the incidence of T1DM is rapidly increasing, which is a serious health problem throughout the world.This review discusses the current ideas about the role of GM in the immunopathogenesis of T1DM, new data on the near-term prospects in the study of the human macrogenome, current ideas about the role of GM in the immunopathogenesis of T1DM, and the possibility of applying this knowledge by the practitioner.
format	article
author	L. I. Ibragimova E. A. Kolpakova A. V. Dzagakhova L. V. Egshatyan E. V. Pokrovskaya O. S. Derevyanko T. V. Nikonova
author_facet	L. I. Ibragimova E. A. Kolpakova A. V. Dzagakhova L. V. Egshatyan E. V. Pokrovskaya O. S. Derevyanko T. V. Nikonova
author_sort	L. I. Ibragimova
title	The role of the gut microbiota in the development of type 1 diabetes mellitus
title_short	The role of the gut microbiota in the development of type 1 diabetes mellitus
title_full	The role of the gut microbiota in the development of type 1 diabetes mellitus
title_fullStr	The role of the gut microbiota in the development of type 1 diabetes mellitus
title_full_unstemmed	The role of the gut microbiota in the development of type 1 diabetes mellitus
title_sort	role of the gut microbiota in the development of type 1 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/2bd2887710424625b52597886d6e70fe
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The role of the gut microbiota in the development of type 1 diabetes mellitus

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