Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ameliorate interleukin-17-mediated joint inflamm...

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Autores principales:	Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be1
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spelling	oai:doaj.org-article:2bd3a4ecc15d4e2986a66ad37a5d8be12021-12-02T14:39:23ZAltered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP7010.1038/s41467-018-05095-72041-1723https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be12018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05095-7https://doaj.org/toc/2041-1723Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ameliorate interleukin-17-mediated joint inflammation.Meng ZhaoMattias N. D. SvenssonKoen VenkenAshu ChawlaShu LiangIsaac EngelPiotr MydelJeremy DayDirk ElewautNunzio BottiniMitchell KronenbergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Zhao Mattias N. D. Svensson Koen Venken Ashu Chawla Shu Liang Isaac Engel Piotr Mydel Jeremy Day Dirk Elewaut Nunzio Bottini Mitchell Kronenberg Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
description	Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ameliorate interleukin-17-mediated joint inflammation.
format	article
author	Meng Zhao Mattias N. D. Svensson Koen Venken Ashu Chawla Shu Liang Isaac Engel Piotr Mydel Jeremy Day Dirk Elewaut Nunzio Bottini Mitchell Kronenberg
author_facet	Meng Zhao Mattias N. D. Svensson Koen Venken Ashu Chawla Shu Liang Isaac Engel Piotr Mydel Jeremy Day Dirk Elewaut Nunzio Bottini Mitchell Kronenberg
author_sort	Meng Zhao
title	Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
title_short	Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
title_full	Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
title_fullStr	Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
title_full_unstemmed	Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
title_sort	altered thymic differentiation and modulation of arthritis by invariant nkt cells expressing mutant zap70
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be1
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Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

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