Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ameliorate interleukin-17-mediated joint inflamm...

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Autores principales: Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/2bd3a4ecc15d4e2986a66ad37a5d8be1
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