Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension

Abstract We have previously shown that elevations in intracranial pressure (ICP) within physiological ranges in normotensive animals increase arterial pressure; termed the intracranial baroreflex. Hypertension is associated with alterations in reflexes which maintain arterial pressure however, wheth...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sydney Vari, Sarah-Jane Guild, Bindu George, Rohit Ramchandra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2bd4f104889d48ca9dac78422c55eedf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2bd4f104889d48ca9dac78422c55eedf
record_format	dspace
spelling	oai:doaj.org-article:2bd4f104889d48ca9dac78422c55eedf2021-12-02T13:16:19ZIntracranial baroreflex is attenuated in an ovine model of renovascular hypertension10.1038/s41598-021-85278-32045-2322https://doaj.org/article/2bd4f104889d48ca9dac78422c55eedf2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85278-3https://doaj.org/toc/2045-2322Abstract We have previously shown that elevations in intracranial pressure (ICP) within physiological ranges in normotensive animals increase arterial pressure; termed the intracranial baroreflex. Hypertension is associated with alterations in reflexes which maintain arterial pressure however, whether the intracranial baroreflex is altered is not known. Hence, in the present study, we tested the hypothesis that in hypertension, physiological increases in ICP would not be accompanied with an increase in arterial pressure. Renovascular hypertension was associated with no change in heart rate, renal blood flow or ICP levels compared to the normotensive group. ICV infusion of saline produced a ramped increase in ICP of 20 ± 1 mmHg. This was accompanied by an increase in arterial pressure (16 ± 2 mmHg) and a significant decrease in renal vascular conductance. ICV infusion of saline in the hypertensive group also increased ICP (19 ± 2 mmHg). However, the increase in arterial pressure was significantly attenuated in the hypertensive group (5 ± 2 mmHg). Ganglionic blockade abolished the increase in arterial pressure in both groups to increased ICP. Our data indicates that physiological increases in ICP lead to increases in arterial pressure in normotensive animals but this is severely attenuated in renovascular hypertension.Sydney VariSarah-Jane GuildBindu GeorgeRohit RamchandraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sydney Vari Sarah-Jane Guild Bindu George Rohit Ramchandra Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension
description	Abstract We have previously shown that elevations in intracranial pressure (ICP) within physiological ranges in normotensive animals increase arterial pressure; termed the intracranial baroreflex. Hypertension is associated with alterations in reflexes which maintain arterial pressure however, whether the intracranial baroreflex is altered is not known. Hence, in the present study, we tested the hypothesis that in hypertension, physiological increases in ICP would not be accompanied with an increase in arterial pressure. Renovascular hypertension was associated with no change in heart rate, renal blood flow or ICP levels compared to the normotensive group. ICV infusion of saline produced a ramped increase in ICP of 20 ± 1 mmHg. This was accompanied by an increase in arterial pressure (16 ± 2 mmHg) and a significant decrease in renal vascular conductance. ICV infusion of saline in the hypertensive group also increased ICP (19 ± 2 mmHg). However, the increase in arterial pressure was significantly attenuated in the hypertensive group (5 ± 2 mmHg). Ganglionic blockade abolished the increase in arterial pressure in both groups to increased ICP. Our data indicates that physiological increases in ICP lead to increases in arterial pressure in normotensive animals but this is severely attenuated in renovascular hypertension.
format	article
author	Sydney Vari Sarah-Jane Guild Bindu George Rohit Ramchandra
author_facet	Sydney Vari Sarah-Jane Guild Bindu George Rohit Ramchandra
author_sort	Sydney Vari
title	Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension
title_short	Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension
title_full	Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension
title_fullStr	Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension
title_full_unstemmed	Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension
title_sort	intracranial baroreflex is attenuated in an ovine model of renovascular hypertension
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2bd4f104889d48ca9dac78422c55eedf
work_keys_str_mv	AT sydneyvari intracranialbaroreflexisattenuatedinanovinemodelofrenovascularhypertension AT sarahjaneguild intracranialbaroreflexisattenuatedinanovinemodelofrenovascularhypertension AT bindugeorge intracranialbaroreflexisattenuatedinanovinemodelofrenovascularhypertension AT rohitramchandra intracranialbaroreflexisattenuatedinanovinemodelofrenovascularhypertension
_version_	1718393324175360000

Intracranial baroreflex is attenuated in an ovine model of renovascular hypertension

Ejemplares similares