Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types

Cell lines are used ubiquitously in cancer research but how well they represent the tumor type they were derived from is variable. Here, the authors compare transcriptomic profiles of 22 tumor types and cell lines and propose a new comprehensive cell line panel for pan-cancer studies.

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Autores principales:	K. Yu, B. Chen, D. Aran, J. Charalel, C. Yau, D. M. Wolf, L. J. van ‘t Veer, A. J. Butte, T. Goldstein, M. Sirota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bd5c7c643b4495ab1808a6fe07e85de
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spelling	oai:doaj.org-article:2bd5c7c643b4495ab1808a6fe07e85de2021-12-02T16:57:46ZComprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types10.1038/s41467-019-11415-22041-1723https://doaj.org/article/2bd5c7c643b4495ab1808a6fe07e85de2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11415-2https://doaj.org/toc/2041-1723Cell lines are used ubiquitously in cancer research but how well they represent the tumor type they were derived from is variable. Here, the authors compare transcriptomic profiles of 22 tumor types and cell lines and propose a new comprehensive cell line panel for pan-cancer studies.K. YuB. ChenD. AranJ. CharalelC. YauD. M. WolfL. J. van ‘t VeerA. J. ButteT. GoldsteinM. SirotaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q K. Yu B. Chen D. Aran J. Charalel C. Yau D. M. Wolf L. J. van ‘t Veer A. J. Butte T. Goldstein M. Sirota Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
description	Cell lines are used ubiquitously in cancer research but how well they represent the tumor type they were derived from is variable. Here, the authors compare transcriptomic profiles of 22 tumor types and cell lines and propose a new comprehensive cell line panel for pan-cancer studies.
format	article
author	K. Yu B. Chen D. Aran J. Charalel C. Yau D. M. Wolf L. J. van ‘t Veer A. J. Butte T. Goldstein M. Sirota
author_facet	K. Yu B. Chen D. Aran J. Charalel C. Yau D. M. Wolf L. J. van ‘t Veer A. J. Butte T. Goldstein M. Sirota
author_sort	K. Yu
title	Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_short	Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_full	Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_fullStr	Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_full_unstemmed	Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
title_sort	comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2bd5c7c643b4495ab1808a6fe07e85de
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Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types

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