Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mouse model of autoimmunity.

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Autores principales: Ahmed T. Kurdi, Ribal Bassil, Marta Olah, Chuan Wu, Sheng Xiao, Mariko Taga, Michael Frangieh, Thomas Buttrick, William Orent, Elizabeth M. Bradshaw, Samia J. Khoury, Wassim Elyaman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2bd631802f2e4fff88549ccea12edba1
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spelling oai:doaj.org-article:2bd631802f2e4fff88549ccea12edba12021-12-02T14:40:13ZTiam1/Rac1 complex controls Il17a transcription and autoimmunity10.1038/ncomms130482041-1723https://doaj.org/article/2bd631802f2e4fff88549ccea12edba12016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13048https://doaj.org/toc/2041-1723Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mouse model of autoimmunity.Ahmed T. KurdiRibal BassilMarta OlahChuan WuSheng XiaoMariko TagaMichael FrangiehThomas ButtrickWilliam OrentElizabeth M. BradshawSamia J. KhouryWassim ElyamanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ahmed T. Kurdi
Ribal Bassil
Marta Olah
Chuan Wu
Sheng Xiao
Mariko Taga
Michael Frangieh
Thomas Buttrick
William Orent
Elizabeth M. Bradshaw
Samia J. Khoury
Wassim Elyaman
Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
description Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mouse model of autoimmunity.
format article
author Ahmed T. Kurdi
Ribal Bassil
Marta Olah
Chuan Wu
Sheng Xiao
Mariko Taga
Michael Frangieh
Thomas Buttrick
William Orent
Elizabeth M. Bradshaw
Samia J. Khoury
Wassim Elyaman
author_facet Ahmed T. Kurdi
Ribal Bassil
Marta Olah
Chuan Wu
Sheng Xiao
Mariko Taga
Michael Frangieh
Thomas Buttrick
William Orent
Elizabeth M. Bradshaw
Samia J. Khoury
Wassim Elyaman
author_sort Ahmed T. Kurdi
title Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
title_short Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
title_full Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
title_fullStr Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
title_full_unstemmed Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
title_sort tiam1/rac1 complex controls il17a transcription and autoimmunity
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/2bd631802f2e4fff88549ccea12edba1
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