Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mouse model of autoimmunity.

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Detalles Bibliográficos
Autores principales: Ahmed T. Kurdi, Ribal Bassil, Marta Olah, Chuan Wu, Sheng Xiao, Mariko Taga, Michael Frangieh, Thomas Buttrick, William Orent, Elizabeth M. Bradshaw, Samia J. Khoury, Wassim Elyaman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/2bd631802f2e4fff88549ccea12edba1
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