IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours

Loss of major histocompatibility complex MHC-I expression contributes to cancer immune evasion. Here, the authors show that, in both mice and humans, MHC-I downregulation is associated with the induction of NK-cell exhaustion and that IL-21 restores NK-cell function and inhibits tumours progression.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyungseok Seo, Insu Jeon, Byung-Seok Kim, Myunghwan Park, Eun-Ah Bae, Boyeong Song, Choong-Hyun Koh, Kwang-Soo Shin, Il-Kyu Kim, Kiyoung Choi, Taegwon Oh, Jiyoun Min, Byung Soh Min, Yoon Dae Han, Suk-Jo Kang, Sang Joon Shin, Yeonseok Chung, Chang-Yuil Kang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bd96612eae447d095ca7886cae7e6ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2bd96612eae447d095ca7886cae7e6ec
record_format	dspace
spelling	oai:doaj.org-article:2bd96612eae447d095ca7886cae7e6ec2021-12-02T15:38:37ZIL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours10.1038/ncomms157762041-1723https://doaj.org/article/2bd96612eae447d095ca7886cae7e6ec2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15776https://doaj.org/toc/2041-1723Loss of major histocompatibility complex MHC-I expression contributes to cancer immune evasion. Here, the authors show that, in both mice and humans, MHC-I downregulation is associated with the induction of NK-cell exhaustion and that IL-21 restores NK-cell function and inhibits tumours progression.Hyungseok SeoInsu JeonByung-Seok KimMyunghwan ParkEun-Ah BaeBoyeong SongChoong-Hyun KohKwang-Soo ShinIl-Kyu KimKiyoung ChoiTaegwon OhJiyoun MinByung Soh MinYoon Dae HanSuk-Jo KangSang Joon ShinYeonseok ChungChang-Yuil KangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyungseok Seo Insu Jeon Byung-Seok Kim Myunghwan Park Eun-Ah Bae Boyeong Song Choong-Hyun Koh Kwang-Soo Shin Il-Kyu Kim Kiyoung Choi Taegwon Oh Jiyoun Min Byung Soh Min Yoon Dae Han Suk-Jo Kang Sang Joon Shin Yeonseok Chung Chang-Yuil Kang IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
description	Loss of major histocompatibility complex MHC-I expression contributes to cancer immune evasion. Here, the authors show that, in both mice and humans, MHC-I downregulation is associated with the induction of NK-cell exhaustion and that IL-21 restores NK-cell function and inhibits tumours progression.
format	article
author	Hyungseok Seo Insu Jeon Byung-Seok Kim Myunghwan Park Eun-Ah Bae Boyeong Song Choong-Hyun Koh Kwang-Soo Shin Il-Kyu Kim Kiyoung Choi Taegwon Oh Jiyoun Min Byung Soh Min Yoon Dae Han Suk-Jo Kang Sang Joon Shin Yeonseok Chung Chang-Yuil Kang
author_facet	Hyungseok Seo Insu Jeon Byung-Seok Kim Myunghwan Park Eun-Ah Bae Boyeong Song Choong-Hyun Koh Kwang-Soo Shin Il-Kyu Kim Kiyoung Choi Taegwon Oh Jiyoun Min Byung Soh Min Yoon Dae Han Suk-Jo Kang Sang Joon Shin Yeonseok Chung Chang-Yuil Kang
author_sort	Hyungseok Seo
title	IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
title_short	IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
title_full	IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
title_fullStr	IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
title_full_unstemmed	IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours
title_sort	il-21-mediated reversal of nk cell exhaustion facilitates anti-tumour immunity in mhc class i-deficient tumours
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2bd96612eae447d095ca7886cae7e6ec
work_keys_str_mv	AT hyungseokseo il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT insujeon il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT byungseokkim il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT myunghwanpark il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT eunahbae il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT boyeongsong il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT choonghyunkoh il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT kwangsooshin il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT ilkyukim il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT kiyoungchoi il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT taegwonoh il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT jiyounmin il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT byungsohmin il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT yoondaehan il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT sukjokang il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT sangjoonshin il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT yeonseokchung il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours AT changyuilkang il21mediatedreversalofnkcellexhaustionfacilitatesantitumourimmunityinmhcclassideficienttumours
_version_	1718386101211627520

IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours

Ejemplares similares