Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration

Tetsuyuki Suetsugu,1,2 Aki Kato,1 Munenori Yoshida,1 Tsutomu Yasukawa,1 Akiko Nishiwaki,1,3 Norio Hasegawa,1 Hideaki Usui,1 Yuichiro Ogura1 1Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 2Department of Ophthalmology, General Kamiiida Dai...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Suetsugu T, Kato A, Yoshida M, Yasukawa T, Nishiwaki A, Hasegawa N, Usui H, Ogura Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	age-related macular degeneration fundus autofluorescence polypoidal choroidal vasculopathy retinal angiomatous proliferation Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2bdec4c31a094feca07d0219ba0ac5c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2bdec4c31a094feca07d0219ba0ac5c1
record_format	dspace
spelling	oai:doaj.org-article:2bdec4c31a094feca07d0219ba0ac5c12021-12-02T02:35:56ZEvaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration1177-5483https://doaj.org/article/2bdec4c31a094feca07d0219ba0ac5c12016-12-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-peripheral-fundus-autofluorescence-in-eyes-with-wet-age--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Tetsuyuki Suetsugu,1,2 Aki Kato,1 Munenori Yoshida,1 Tsutomu Yasukawa,1 Akiko Nishiwaki,1,3 Norio Hasegawa,1 Hideaki Usui,1 Yuichiro Ogura1 1Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 2Department of Ophthalmology, General Kamiiida Daiichi Hospital, 3Nishiwaki Eye Clinic, Nagoya, Aichi, Japan Purpose: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. Patients and methods: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. Results: Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes. Conclusion: Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes. Keywords: age-related macular degeneration, fundus autofluorescence, polypoidal choroidal vasculopathy, retinal angiomatous proliferation Suetsugu TKato AYoshida MYasukawa TNishiwaki AHasegawa NUsui HOgura YDove Medical Pressarticleage-related macular degenerationfundus autofluorescencepolypoidal choroidal vasculopathyretinal angiomatous proliferationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 2497-2503 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	age-related macular degeneration fundus autofluorescence polypoidal choroidal vasculopathy retinal angiomatous proliferation Ophthalmology RE1-994
spellingShingle	age-related macular degeneration fundus autofluorescence polypoidal choroidal vasculopathy retinal angiomatous proliferation Ophthalmology RE1-994 Suetsugu T Kato A Yoshida M Yasukawa T Nishiwaki A Hasegawa N Usui H Ogura Y Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
description	Tetsuyuki Suetsugu,1,2 Aki Kato,1 Munenori Yoshida,1 Tsutomu Yasukawa,1 Akiko Nishiwaki,1,3 Norio Hasegawa,1 Hideaki Usui,1 Yuichiro Ogura1 1Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 2Department of Ophthalmology, General Kamiiida Daiichi Hospital, 3Nishiwaki Eye Clinic, Nagoya, Aichi, Japan Purpose: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. Patients and methods: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients). Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. Results: Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001). Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7%) showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively) than control eyes (18.8%). There were no significant differences (P=0.76) between the frequencies in untreated and treated eyes. Conclusion: Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes. Keywords: age-related macular degeneration, fundus autofluorescence, polypoidal choroidal vasculopathy, retinal angiomatous proliferation
format	article
author	Suetsugu T Kato A Yoshida M Yasukawa T Nishiwaki A Hasegawa N Usui H Ogura Y
author_facet	Suetsugu T Kato A Yoshida M Yasukawa T Nishiwaki A Hasegawa N Usui H Ogura Y
author_sort	Suetsugu T
title	Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_short	Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_full	Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_fullStr	Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_full_unstemmed	Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
title_sort	evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2bdec4c31a094feca07d0219ba0ac5c1
work_keys_str_mv	AT suetsugut evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration AT katoa evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration AT yoshidam evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration AT yasukawat evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration AT nishiwakia evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration AT hasegawan evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration AT usuih evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration AT oguray evaluationofperipheralfundusautofluorescenceineyeswithwetagerelatedmaculardegeneration
_version_	1718402337335148544

Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration

Ejemplares similares