Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line

Andreza S Figueiredo,1 Hiram J García-Crescioni,1 Sandra C Bulla,1 Matthew K Ross,2 Chelsea McIntosh,1 Kari Lunsford,3 Camilo Bulla11Department of Pathobiology and Population Medicine, 2Department of Basic Sciences, 3Department of Clinical Sciences and Animal Health Center, College of Vet...

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Autores principales:	Figueiredo AS, Garc&iacute;a-Crescioni HJ, Bulla SC, Ross MK, McIntosh C, Lunsford K, Bulla C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/2be8851dfa0b463c94051be2775efeb1
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spelling	oai:doaj.org-article:2be8851dfa0b463c94051be2775efeb12021-12-02T02:18:48ZSuppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line2230-2034https://doaj.org/article/2be8851dfa0b463c94051be2775efeb12013-07-01T00:00:00Zhttp://www.dovepress.com/suppression-of-vascular-endothelial-growth-factor-expression-by-cannab-a13597https://doaj.org/toc/2230-2034Andreza S Figueiredo,1 Hiram J García-Crescioni,1 Sandra C Bulla,1 Matthew K Ross,2 Chelsea McIntosh,1 Kari Lunsford,3 Camilo Bulla11Department of Pathobiology and Population Medicine, 2Department of Basic Sciences, 3Department of Clinical Sciences and Animal Health Center, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USAAbstract: Vascular endothelial growth factor (VEGF) is a key regulator in both physiologic and pathologic angiogenesis, and cannabinoids decrease VEGF release in human and murine cancer cells. The aim of this study was to assess the in vitro effects of a synthetic cannabinoid, WIN-55,212-2, on the expression of the proangiogenic factor VEGF-A in the canine osteosarcoma cell line 8. After analysis of gene expression by quantitative real-time polymerase chain reaction, the compound decreased VEGF-A expression by 35% ± 10% (P < 0.0001) as compared with the control. This synthetic cannabinoid shows promise as a potential inhibitor of angiogenesis, and further studies are warranted to investigate its in vivo effects and to explore the potential of this and related compounds as adjuvant cancer therapy in the dog.Keywords: dog, cancer, angiogenesis, cannabinoidsFigueiredo ASGarc&iacute;a-Crescioni HJBulla SCRoss MKMcIntosh CLunsford KBulla CDove Medical PressarticleVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol 2013, Iss default, Pp 31-34 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Veterinary medicine SF600-1100
spellingShingle	Veterinary medicine SF600-1100 Figueiredo AS Garc&iacute;a-Crescioni HJ Bulla SC Ross MK McIntosh C Lunsford K Bulla C Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line
description	Andreza S Figueiredo,1 Hiram J García-Crescioni,1 Sandra C Bulla,1 Matthew K Ross,2 Chelsea McIntosh,1 Kari Lunsford,3 Camilo Bulla11Department of Pathobiology and Population Medicine, 2Department of Basic Sciences, 3Department of Clinical Sciences and Animal Health Center, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USAAbstract: Vascular endothelial growth factor (VEGF) is a key regulator in both physiologic and pathologic angiogenesis, and cannabinoids decrease VEGF release in human and murine cancer cells. The aim of this study was to assess the in vitro effects of a synthetic cannabinoid, WIN-55,212-2, on the expression of the proangiogenic factor VEGF-A in the canine osteosarcoma cell line 8. After analysis of gene expression by quantitative real-time polymerase chain reaction, the compound decreased VEGF-A expression by 35% ± 10% (P < 0.0001) as compared with the control. This synthetic cannabinoid shows promise as a potential inhibitor of angiogenesis, and further studies are warranted to investigate its in vivo effects and to explore the potential of this and related compounds as adjuvant cancer therapy in the dog.Keywords: dog, cancer, angiogenesis, cannabinoids
format	article
author	Figueiredo AS Garc&iacute;a-Crescioni HJ Bulla SC Ross MK McIntosh C Lunsford K Bulla C
author_facet	Figueiredo AS Garc&iacute;a-Crescioni HJ Bulla SC Ross MK McIntosh C Lunsford K Bulla C
author_sort	Figueiredo AS
title	Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line
title_short	Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line
title_full	Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line
title_fullStr	Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line
title_full_unstemmed	Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line
title_sort	suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/2be8851dfa0b463c94051be2775efeb1
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Suppression of vascular endothelial growth factor expression by cannabinoids in a canine osteosarcoma cell line

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