Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic

Purpose. Determination of the SARS-CoV-2 population humoral immunity among the population of the Krasnoyarsk Territory during the COVID-19 epidemic.Materials and methods. The study was carried out as a part of project for assessing population immunity to SARS-CoV-2 among the population of Russian Fe...

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Autores principales:	A. Yu. Popova, E. B. Ezhlova, A. A. Melnikova, V. S. Smirnov, L. V. Lyalina, D. V. Goryaev, D. A. Khodov, T. G. Chepizhko, M. V. Rusin, N. N. Kuznetsova, E. Yu. Bezruchko, A. S. Kochergina, V. R. Karimov, A. A. Sharova, V. V. Vetrov, A. A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	coronaviruses sars-cov-2 covid-19 population immunity seroprevalence morbidity krasnoyarsk territory population Science Q
Acceso en línea:	https://doaj.org/article/2beb24b2311644a18971c856f09e63e7
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spelling	oai:doaj.org-article:2beb24b2311644a18971c856f09e63e72021-11-23T06:14:46ZStructure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic2541-94202587-959610.29413/ABS.2021-6.3.23https://doaj.org/article/2beb24b2311644a18971c856f09e63e72021-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2872https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Purpose. Determination of the SARS-CoV-2 population humoral immunity among the population of the Krasnoyarsk Territory during the COVID-19 epidemic.Materials and methods. The study was carried out as a part of project for assessing population immunity to SARS-CoV-2 among the population of Russian Federation using unified methodology developed by Rospotrebnadzor, with the participation of the Research Institute for Epidemiology and Microbiology named by Pasteur, and taking into account the recommendations of the WHO. The work involved 2907 volunteers, selected by the online survey and randomization by age and territory. All volunteers were divided into 7 age groups: 1–17, 18–29, 30–39, 40–49, 50–59, 60–69, 70 and older (70+), including a total 246–449 people. Population immunity testing was carried out during the formation of groups (1st stage), and then twice more, with the interval of 6–8 weeks. Serum was obtained from venous blood samples obtained from volunteers, in which antibodies to the SARS-CoV-2 nucleocapsid were determined by the enzyme immunoassay. The results were analyzed by methods of nonparametric statistics: median, interquartile range, rank correlation coefficient were calculated in the Excel statistical package. The confidence interval to seroprevalence indicators (95% CI) was calculated using the WinPepi statistical package (version 11.65). The statistical significance of the differences was assessed with a probability level of p ≤ 0.05.Results. The seroprevalence of the population of the Krasnoyarsk Territory during the 5-month period of seromonitoring had increased 3.3 times from 12.8% (95% CI 11.3–14.4) to 41.7% (95% CI 39.4–4.0) , while the grouping by age had not revealed any peculiarities throughout the study. The trend towards a decrease in the incidence was formed on the 6th week of 2021. The seroprevalence of convalescents after COVID-19 during the initial testing was 61.5% (95% CI 40,6–79.8), among those who were in contact with patients with COVID-19 or convalescents –23.8% (95% CI 13.9–36.2) . Among the volunteers, 347 seropositive persons were identified, 324 of which were observed asymptomatic course.Conclusion. The structure of the population humoral immunity to SARS-CoV-2 of he population of the Krasnoyarsk Territory has been investigated. It was found that an increase in seroprevalence to 41.7% (95% CI 39.4–4.0) was accompanied by a decrease in morbidity.A. Yu. PopovaE. B. EzhlovaA. A. MelnikovaV. S. SmirnovL. V. LyalinaD. V. GoryaevD. A. KhodovT. G. ChepizhkoM. V. RusinN. N. KuznetsovaE. Yu. BezruchkoA. S. KocherginaV. R. KarimovA. A. SharovaV. V. VetrovA. A. TotolianScientific Сentre for Family Health and Human Reproduction Problemsarticlecoronavirusessars-cov-2covid-19population immunityseroprevalencemorbiditykrasnoyarsk territorypopulationScienceQRUActa Biomedica Scientifica, Vol 6, Iss 3, Pp 227-238 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	coronaviruses sars-cov-2 covid-19 population immunity seroprevalence morbidity krasnoyarsk territory population Science Q
spellingShingle	coronaviruses sars-cov-2 covid-19 population immunity seroprevalence morbidity krasnoyarsk territory population Science Q A. Yu. Popova E. B. Ezhlova A. A. Melnikova V. S. Smirnov L. V. Lyalina D. V. Goryaev D. A. Khodov T. G. Chepizhko M. V. Rusin N. N. Kuznetsova E. Yu. Bezruchko A. S. Kochergina V. R. Karimov A. A. Sharova V. V. Vetrov A. A. Totolian Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic
description	Purpose. Determination of the SARS-CoV-2 population humoral immunity among the population of the Krasnoyarsk Territory during the COVID-19 epidemic.Materials and methods. The study was carried out as a part of project for assessing population immunity to SARS-CoV-2 among the population of Russian Federation using unified methodology developed by Rospotrebnadzor, with the participation of the Research Institute for Epidemiology and Microbiology named by Pasteur, and taking into account the recommendations of the WHO. The work involved 2907 volunteers, selected by the online survey and randomization by age and territory. All volunteers were divided into 7 age groups: 1–17, 18–29, 30–39, 40–49, 50–59, 60–69, 70 and older (70+), including a total 246–449 people. Population immunity testing was carried out during the formation of groups (1st stage), and then twice more, with the interval of 6–8 weeks. Serum was obtained from venous blood samples obtained from volunteers, in which antibodies to the SARS-CoV-2 nucleocapsid were determined by the enzyme immunoassay. The results were analyzed by methods of nonparametric statistics: median, interquartile range, rank correlation coefficient were calculated in the Excel statistical package. The confidence interval to seroprevalence indicators (95% CI) was calculated using the WinPepi statistical package (version 11.65). The statistical significance of the differences was assessed with a probability level of p ≤ 0.05.Results. The seroprevalence of the population of the Krasnoyarsk Territory during the 5-month period of seromonitoring had increased 3.3 times from 12.8% (95% CI 11.3–14.4) to 41.7% (95% CI 39.4–4.0) , while the grouping by age had not revealed any peculiarities throughout the study. The trend towards a decrease in the incidence was formed on the 6th week of 2021. The seroprevalence of convalescents after COVID-19 during the initial testing was 61.5% (95% CI 40,6–79.8), among those who were in contact with patients with COVID-19 or convalescents –23.8% (95% CI 13.9–36.2) . Among the volunteers, 347 seropositive persons were identified, 324 of which were observed asymptomatic course.Conclusion. The structure of the population humoral immunity to SARS-CoV-2 of he population of the Krasnoyarsk Territory has been investigated. It was found that an increase in seroprevalence to 41.7% (95% CI 39.4–4.0) was accompanied by a decrease in morbidity.
format	article
author	A. Yu. Popova E. B. Ezhlova A. A. Melnikova V. S. Smirnov L. V. Lyalina D. V. Goryaev D. A. Khodov T. G. Chepizhko M. V. Rusin N. N. Kuznetsova E. Yu. Bezruchko A. S. Kochergina V. R. Karimov A. A. Sharova V. V. Vetrov A. A. Totolian
author_facet	A. Yu. Popova E. B. Ezhlova A. A. Melnikova V. S. Smirnov L. V. Lyalina D. V. Goryaev D. A. Khodov T. G. Chepizhko M. V. Rusin N. N. Kuznetsova E. Yu. Bezruchko A. S. Kochergina V. R. Karimov A. A. Sharova V. V. Vetrov A. A. Totolian
author_sort	A. Yu. Popova
title	Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic
title_short	Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic
title_full	Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic
title_fullStr	Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic
title_full_unstemmed	Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic
title_sort	structure of herd immunity to sars-cov-2 in the krasnoyarsk region population in the covid-19 epidemic
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/2beb24b2311644a18971c856f09e63e7
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Structure of herd immunity to SARS-COV-2 in the Krasnoyarsk region population in the COVID-19 epidemic

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