Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

Despite the presence of tumor-infiltrating lymphocytes, many patients do not respond to PD-L1/PD-1 blockade therapy. Here they show that PD-L1 antibody armed with interferon-α (IFNα) improves tumor targeting and antigen presentation while countering innate or T-cell-drive PD-L1 upregulation, and ove...

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Autores principales:	Yong Liang, Haidong Tang, Jingya Guo, Xiangyan Qiu, Zecheng Yang, Zhenhua Ren, Zhichen Sun, Yingjie Bian, Lily Xu, Hairong Xu, Jiao Shen, Yanfei Han, Haidong Dong, Hua Peng, Yang-Xin Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bec0b96f87441938ab682d97415c845
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spelling	oai:doaj.org-article:2bec0b96f87441938ab682d97415c8452021-12-02T15:33:41ZTargeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance10.1038/s41467-018-06890-y2041-1723https://doaj.org/article/2bec0b96f87441938ab682d97415c8452018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06890-yhttps://doaj.org/toc/2041-1723Despite the presence of tumor-infiltrating lymphocytes, many patients do not respond to PD-L1/PD-1 blockade therapy. Here they show that PD-L1 antibody armed with interferon-α (IFNα) improves tumor targeting and antigen presentation while countering innate or T-cell-drive PD-L1 upregulation, and overcomes resistance to checkpoint blockade therapy.Yong LiangHaidong TangJingya GuoXiangyan QiuZecheng YangZhenhua RenZhichen SunYingjie BianLily XuHairong XuJiao ShenYanfei HanHaidong DongHua PengYang-Xin FuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong Liang Haidong Tang Jingya Guo Xiangyan Qiu Zecheng Yang Zhenhua Ren Zhichen Sun Yingjie Bian Lily Xu Hairong Xu Jiao Shen Yanfei Han Haidong Dong Hua Peng Yang-Xin Fu Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
description	Despite the presence of tumor-infiltrating lymphocytes, many patients do not respond to PD-L1/PD-1 blockade therapy. Here they show that PD-L1 antibody armed with interferon-α (IFNα) improves tumor targeting and antigen presentation while countering innate or T-cell-drive PD-L1 upregulation, and overcomes resistance to checkpoint blockade therapy.
format	article
author	Yong Liang Haidong Tang Jingya Guo Xiangyan Qiu Zecheng Yang Zhenhua Ren Zhichen Sun Yingjie Bian Lily Xu Hairong Xu Jiao Shen Yanfei Han Haidong Dong Hua Peng Yang-Xin Fu
author_facet	Yong Liang Haidong Tang Jingya Guo Xiangyan Qiu Zecheng Yang Zhenhua Ren Zhichen Sun Yingjie Bian Lily Xu Hairong Xu Jiao Shen Yanfei Han Haidong Dong Hua Peng Yang-Xin Fu
author_sort	Yong Liang
title	Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
title_short	Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
title_full	Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
title_fullStr	Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
title_full_unstemmed	Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
title_sort	targeting ifnα to tumor by anti-pd-l1 creates feedforward antitumor responses to overcome checkpoint blockade resistance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2bec0b96f87441938ab682d97415c845
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Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

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