Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

The DNA ligase of African swine fever virus is one of the most error-prone ligases identified to date, but underlying molecular details are lacking. Here, Chen et al. report four AsfvLIG:DNA structures and identify a unique N-terminal domain and four unique active site residues that are crucial for...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yiqing Chen, Hehua Liu, Chun Yang, Yanqing Gao, Xiang Yu, Xi Chen, Ruixue Cui, Lina Zheng, Suhua Li, Xuhang Li, Jinbiao Ma, Zhen Huang, Jixi Li, Jianhua Gan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bedf69d630b4905bf64d70caac45ee1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2bedf69d630b4905bf64d70caac45ee1
record_format	dspace
spelling	oai:doaj.org-article:2bedf69d630b4905bf64d70caac45ee12021-12-02T17:01:53ZStructure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues10.1038/s41467-019-08296-w2041-1723https://doaj.org/article/2bedf69d630b4905bf64d70caac45ee12019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08296-whttps://doaj.org/toc/2041-1723The DNA ligase of African swine fever virus is one of the most error-prone ligases identified to date, but underlying molecular details are lacking. Here, Chen et al. report four AsfvLIG:DNA structures and identify a unique N-terminal domain and four unique active site residues that are crucial for its catalytic efficiency.Yiqing ChenHehua LiuChun YangYanqing GaoXiang YuXi ChenRuixue CuiLina ZhengSuhua LiXuhang LiJinbiao MaZhen HuangJixi LiJianhua GanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yiqing Chen Hehua Liu Chun Yang Yanqing Gao Xiang Yu Xi Chen Ruixue Cui Lina Zheng Suhua Li Xuhang Li Jinbiao Ma Zhen Huang Jixi Li Jianhua Gan Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
description	The DNA ligase of African swine fever virus is one of the most error-prone ligases identified to date, but underlying molecular details are lacking. Here, Chen et al. report four AsfvLIG:DNA structures and identify a unique N-terminal domain and four unique active site residues that are crucial for its catalytic efficiency.
format	article
author	Yiqing Chen Hehua Liu Chun Yang Yanqing Gao Xiang Yu Xi Chen Ruixue Cui Lina Zheng Suhua Li Xuhang Li Jinbiao Ma Zhen Huang Jixi Li Jianhua Gan
author_facet	Yiqing Chen Hehua Liu Chun Yang Yanqing Gao Xiang Yu Xi Chen Ruixue Cui Lina Zheng Suhua Li Xuhang Li Jinbiao Ma Zhen Huang Jixi Li Jianhua Gan
author_sort	Yiqing Chen
title	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
title_short	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
title_full	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
title_fullStr	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
title_full_unstemmed	Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues
title_sort	structure of the error-prone dna ligase of african swine fever virus identifies critical active site residues
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2bedf69d630b4905bf64d70caac45ee1
work_keys_str_mv	AT yiqingchen structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT hehualiu structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT chunyang structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT yanqinggao structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT xiangyu structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT xichen structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT ruixuecui structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT linazheng structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT suhuali structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT xuhangli structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT jinbiaoma structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT zhenhuang structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT jixili structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues AT jianhuagan structureoftheerrorpronednaligaseofafricanswinefevervirusidentifiescriticalactivesiteresidues
_version_	1718382018031517696

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

Ejemplares similares