Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines

Due to their poor electrophilicity, 2H-azirines do not easily react with nucleophiles. Here, the authors show an acidic activation of 2H-azirines by cyanoacetic acid coupling partners affording chiral aziridines containing vicinal tetrasubstituted and acyclic quaternary stereogenic carbon centers.

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Autores principales:	Hai-Jun Zhang, Yan-Cheng Xie, Liang Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bf13af7983245749c439a0fd81e5be5
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spelling	oai:doaj.org-article:2bf13af7983245749c439a0fd81e5be52021-12-02T17:01:52ZCopper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines10.1038/s41467-019-09750-52041-1723https://doaj.org/article/2bf13af7983245749c439a0fd81e5be52019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09750-5https://doaj.org/toc/2041-1723Due to their poor electrophilicity, 2H-azirines do not easily react with nucleophiles. Here, the authors show an acidic activation of 2H-azirines by cyanoacetic acid coupling partners affording chiral aziridines containing vicinal tetrasubstituted and acyclic quaternary stereogenic carbon centers.Hai-Jun ZhangYan-Cheng XieLiang YinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hai-Jun Zhang Yan-Cheng Xie Liang Yin Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
description	Due to their poor electrophilicity, 2H-azirines do not easily react with nucleophiles. Here, the authors show an acidic activation of 2H-azirines by cyanoacetic acid coupling partners affording chiral aziridines containing vicinal tetrasubstituted and acyclic quaternary stereogenic carbon centers.
format	article
author	Hai-Jun Zhang Yan-Cheng Xie Liang Yin
author_facet	Hai-Jun Zhang Yan-Cheng Xie Liang Yin
author_sort	Hai-Jun Zhang
title	Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
title_short	Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
title_full	Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
title_fullStr	Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
title_full_unstemmed	Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines
title_sort	copper(i)-catalyzed asymmetric decarboxylative mannich reaction enabled by acidic activation of 2h-azirines
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2bf13af7983245749c439a0fd81e5be5
work_keys_str_mv	AT haijunzhang coppericatalyzedasymmetricdecarboxylativemannichreactionenabledbyacidicactivationof2hazirines AT yanchengxie coppericatalyzedasymmetricdecarboxylativemannichreactionenabledbyacidicactivationof2hazirines AT liangyin coppericatalyzedasymmetricdecarboxylativemannichreactionenabledbyacidicactivationof2hazirines
_version_	1718382018221309952

Copper(I)-catalyzed asymmetric decarboxylative Mannich reaction enabled by acidic activation of 2H-azirines

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